Document Detail

When to suspect and how to monitor babesiosis.
MedLine Citation:
PMID:  11388711     Owner:  NLM     Status:  MEDLINE    
In the past decade, cases of babesiosis in humans have been reported with increasing frequency, especially in the northeastern United States. Babesia microti (in the United States) and bovine strains (in Europe) cause most infections in humans. Most cases are tick-borne, although cases of transfusion-associated and transplacental/perinatal transmission have also been reported. Factors associated with more severe disease include advanced age, previous splenectomy and immunodeficient states. Symptoms include high fever, chills, diaphoresis, weakness, anorexia and headache. Later in the course of the illness, the patient may develop jaundice. Congestive heart failure, renal failure and acute respiratory distress syndrome are the most common complications. Therapy using the combination of quinine sulfate and clindamycin was the most commonly used treatment; however, atovaquone suspension plus azithromycin was recently reported an equally effective and less toxic therapy. Exchange transfusion, together with antibabesial chemotherapy, may be necessary in critically ill patients.
E Mylonakis
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Review    
Journal Detail:
Title:  American family physician     Volume:  63     ISSN:  0002-838X     ISO Abbreviation:  Am Fam Physician     Publication Date:  2001 May 
Date Detail:
Created Date:  2001-06-04     Completed Date:  2001-06-28     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  1272646     Medline TA:  Am Fam Physician     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1969-74     Citation Subset:  AIM; IM    
Infectious Diseases Division, Massachusetts General Hospital, Boston 02114, USA.
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MeSH Terms
Anti-Bacterial Agents / therapeutic use
Antimalarials / therapeutic use
Arachnid Vectors / parasitology
Babesiosis / diagnosis*,  epidemiology,  etiology,  parasitology,  therapy*
Blood Transfusion / adverse effects
Endemic Diseases / prevention & control,  statistics & numerical data
Primary Prevention / methods
Risk Factors
Ticks / parasitology
United States / epidemiology
Reg. No./Substance:
0/Anti-Bacterial Agents; 0/Antimalarials

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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