Document Detail


When to image carotid plaque inflammation with FDG PET/CT.
MedLine Citation:
PMID:  20543757     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
OBJECTIVE: Quantification of 18-fluorodeoxyglucose (FDG) uptake in inflamed high-risk carotid atherosclerotic plaques is challenged by the spatial resolution of positron emission tomography (PET) and luminal blood activity. Late acquisition protocols have been used to overcome these challenges to enhance the contrast between the plaque and blood-pool FDG activity. However, for prospective studies the late acquisition is inconvenient for the patient and staff, and most retrospective studies of plaque uptake use data from early acquisition protocols. The objective was to evaluate changes in the quantification methods of FDG uptake in carotid artery plaques between early and late PET scans.
METHODS: FDG uptake 1 and 3 h after tracer injection was compared in 19 carotid artery plaques. The average plaque maximum standardized uptake value (SUVmax) and a target to background ratio (TBR), using venous blood-pool activity as background, were evaluated at the two time points. These methods have been shown earlier to quantitate the degree of inflammation in late hour scans.
RESULTS: A good individual plaque FDG uptake consistency was found between the two time points for SUVmax, r²=0.86. In contrast, the ratio method did not conserve the results between the two time points: TBR r²=0.34. For both methods, absolute values changed over time. TBR values generally increased as blood pool activity decreased, whereas the individual plaque SUVmax values showed both increases and decreases over time.
CONCLUSION: Identification of carotid plaque inflammation with PET can be performed 1 h after FDG injection using SUVmax for plaque FDG uptake quantification.
Authors:
Martin Graebe; Lise Borgwardt; Liselotte Højgaard; Henrik Sillesen; Andreas Kjaer
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Publication Detail:
Type:  Clinical Trial; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Nuclear medicine communications     Volume:  31     ISSN:  1473-5628     ISO Abbreviation:  Nucl Med Commun     Publication Date:  2010 Sep 
Date Detail:
Created Date:  2010-10-05     Completed Date:  2011-01-18     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8201017     Medline TA:  Nucl Med Commun     Country:  England    
Other Details:
Languages:  eng     Pagination:  773-9     Citation Subset:  IM    
Affiliation:
Department of Vascular Surgery, Rigshospitalet, University of Copenhagen, Denmark. martin.graebe@rh.regionh.dk
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MeSH Terms
Descriptor/Qualifier:
Aged
Aged, 80 and over
Biological Transport
Carotid Stenosis / complications*,  diagnosis*,  metabolism
Feasibility Studies
Female
Fluorodeoxyglucose F18 / administration & dosage,  diagnostic use*,  metabolism
Humans
Image Processing, Computer-Assisted
Inflammation / complications,  diagnosis,  metabolism
Injections
Male
Middle Aged
Positron-Emission Tomography / methods*
Time Factors
Tomography, X-Ray Computed / methods*
Chemical
Reg. No./Substance:
63503-12-8/Fluorodeoxyglucose F18

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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