Document Detail

When neighbourhood matters: tumour microenvironment.
MedLine Citation:
PMID:  19211370     Owner:  NLM     Status:  MEDLINE    
Tumour development comprises a complex succession of events that prompt incipient cancer cells to proliferate out of control and to acquire migratory and invasive capabilities. Over the past decades, cancer research has produced a wealth of knowledge about the intrinsic alterations of neoplastic cells within tumours. However, tumours now have come to be understood to function as complex tissues in which numerous cells, collectively termed the tumour microenvironment, play a critical role. These include inflammatory cells, blood vessels, fibroblasts and changes in their secreted extracellular matrix. This is revealing additional mechanisms of tumorigenesis that has spawned a new era of therapeutic strategies aimed at eradicating tumours.
M Pérez-Moreno
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico     Volume:  11     ISSN:  1699-048X     ISO Abbreviation:  -     Publication Date:  2009 Feb 
Date Detail:
Created Date:  2009-02-12     Completed Date:  2009-06-18     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101247119     Medline TA:  Clin Transl Oncol     Country:  Spain    
Other Details:
Languages:  eng     Pagination:  70-4     Citation Subset:  IM    
Epithelial Cell Biology Group, Cancer Cell Biology Program, Spanish National Cancer Center (CNIO), Madrid, Spain.
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MeSH Terms
Inflammation / complications*
Models, Biological
Neoplasm Invasiveness
Neoplasm Metastasis
Neoplasms / immunology*,  pathology,  therapy

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