| When neighbourhood matters: tumour microenvironment. | |
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MedLine Citation:
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PMID: 19211370 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Tumour development comprises a complex succession of events that prompt incipient cancer cells to proliferate out of control and to acquire migratory and invasive capabilities. Over the past decades, cancer research has produced a wealth of knowledge about the intrinsic alterations of neoplastic cells within tumours. However, tumours now have come to be understood to function as complex tissues in which numerous cells, collectively termed the tumour microenvironment, play a critical role. These include inflammatory cells, blood vessels, fibroblasts and changes in their secreted extracellular matrix. This is revealing additional mechanisms of tumorigenesis that has spawned a new era of therapeutic strategies aimed at eradicating tumours. |
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Authors:
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M Pérez-Moreno |
Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico Volume: 11 ISSN: 1699-048X ISO Abbreviation: - Publication Date: 2009 Feb |
Date Detail:
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Created Date: 2009-02-12 Completed Date: 2009-06-18 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 101247119 Medline TA: Clin Transl Oncol Country: Spain |
Other Details:
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Languages: eng Pagination: 70-4 Citation Subset: IM |
Affiliation:
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Epithelial Cell Biology Group, Cancer Cell Biology Program, Spanish National Cancer Center (CNIO), Madrid, Spain. maperez@cnio.es |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Humans Inflammation / complications* Models, Biological Neoplasm Invasiveness Neoplasm Metastasis Neoplasms / immunology*, pathology, therapy |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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