Document Detail

When epilepsy interferes with word comprehension: findings in Landau-Kleffner syndrome.
MedLine Citation:
PMID:  18184944     Owner:  NLM     Status:  MEDLINE    
Landau-Kleffner syndrome is characterized by a regression in receptive language. The factors that affect the clinical expression of this syndrome remain unclear. This study presents neuroimaging findings in 2 patients showing different clinical evolutions. Linguistic regression persisted in 1 patient and evolved positively in the other. In patient A (with severe linguistic regression) there was an overlap between areas engaged during word recognition and those involved in generating the epileptiform activity; in patient B (with better linguistic evolution), receptive language was predominantly represented in the right hemisphere (unaffected). Patient A underwent multiple subpial transections. The 2-year follow-up indicated linguistic improvement, absence of epileptiform activity, and activation of the left temporal cortex during word comprehension. These results suggest that the resolution of the linguistic deficit in Landau-Kleffner syndrome may be modulated by the language-specific cortex freed from interfering epileptiform activity or by reorganization of the receptive language cortex triggered by the epileptic activity.
Eduardo M Castillo; Ian J Butler; James E Baumgartner; Antony Passaro; Andrew C Papanicolaou
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Publication Detail:
Type:  Case Reports; Journal Article    
Journal Detail:
Title:  Journal of child neurology     Volume:  23     ISSN:  0883-0738     ISO Abbreviation:  J. Child Neurol.     Publication Date:  2008 Jan 
Date Detail:
Created Date:  2008-01-10     Completed Date:  2008-03-07     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8606714     Medline TA:  J Child Neurol     Country:  Canada    
Other Details:
Languages:  eng     Pagination:  97-101     Citation Subset:  IM    
Department of Pediatrics, University of Texas-Houston Medical School, Houston, TX 77030, USA.
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MeSH Terms
Adaptation, Physiological / physiology
Aphasia, Wernicke / diagnosis,  etiology,  physiopathology
Brain Mapping
Cerebral Cortex / anatomy & histology,  physiopathology
Dominance, Cerebral / physiology
Epilepsy / complications*,  physiopathology
Landau-Kleffner Syndrome / complications*,  physiopathology
Language Development Disorders / diagnosis,  etiology*,  physiopathology*
Neuronal Plasticity / physiology
Recovery of Function / physiology
Regression (Psychology)
Speech Perception / physiology
Temporal Lobe / anatomy & histology,  physiology
Verbal Behavior / physiology

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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