| When epilepsy interferes with word comprehension: findings in Landau-Kleffner syndrome. | |
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MedLine Citation:
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PMID: 18184944 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Landau-Kleffner syndrome is characterized by a regression in receptive language. The factors that affect the clinical expression of this syndrome remain unclear. This study presents neuroimaging findings in 2 patients showing different clinical evolutions. Linguistic regression persisted in 1 patient and evolved positively in the other. In patient A (with severe linguistic regression) there was an overlap between areas engaged during word recognition and those involved in generating the epileptiform activity; in patient B (with better linguistic evolution), receptive language was predominantly represented in the right hemisphere (unaffected). Patient A underwent multiple subpial transections. The 2-year follow-up indicated linguistic improvement, absence of epileptiform activity, and activation of the left temporal cortex during word comprehension. These results suggest that the resolution of the linguistic deficit in Landau-Kleffner syndrome may be modulated by the language-specific cortex freed from interfering epileptiform activity or by reorganization of the receptive language cortex triggered by the epileptic activity. |
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Authors:
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Eduardo M Castillo; Ian J Butler; James E Baumgartner; Antony Passaro; Andrew C Papanicolaou |
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Publication Detail:
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Type: Case Reports; Journal Article |
Journal Detail:
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Title: Journal of child neurology Volume: 23 ISSN: 0883-0738 ISO Abbreviation: J. Child Neurol. Publication Date: 2008 Jan |
Date Detail:
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Created Date: 2008-01-10 Completed Date: 2008-03-07 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8606714 Medline TA: J Child Neurol Country: Canada |
Other Details:
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Languages: eng Pagination: 97-101 Citation Subset: IM |
Affiliation:
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Department of Pediatrics, University of Texas-Houston Medical School, Houston, TX 77030, USA. eduardo.m.castillo@uth.tmc.edu |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adaptation, Physiological
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physiology Adolescent Aphasia, Wernicke / diagnosis, etiology, physiopathology Brain Mapping Cerebral Cortex / anatomy & histology, physiopathology Child Dominance, Cerebral / physiology Epilepsy / complications*, physiopathology Female Humans Landau-Kleffner Syndrome / complications*, physiopathology Language Development Disorders / diagnosis, etiology*, physiopathology* Magnetoencephalography Neuronal Plasticity / physiology Recovery of Function / physiology Regression (Psychology) Speech Perception / physiology Temporal Lobe / anatomy & histology, physiology Verbal Behavior / physiology |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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