| When does age-related cognitive decline begin? | |
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MedLine Citation:
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PMID: 19231028 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Cross-sectional comparisons have consistently revealed that increased age is associated with lower levels of cognitive performance, even in the range from 18 to 60 years of age. However, the validity of cross-sectional comparisons of cognitive functioning in young and middle-aged adults has been questioned because of the discrepant age trends found in longitudinal and cross-sectional analyses. The results of the current project suggest that a major factor contributing to the discrepancy is the masking of age-related declines in longitudinal comparisons by large positive effects associated with prior test experience. Results from three methods of estimating retest effects in this project, together with results from studies comparing non-human animals raised in constant environments and from studies examining neurobiological variables not susceptible to retest effects, converge on a conclusion that some aspects of age-related cognitive decline begin in healthy educated adults when they are in their 20s and 30s. |
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Authors:
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Timothy A Salthouse |
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Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural Date: 2009-02-20 |
Journal Detail:
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Title: Neurobiology of aging Volume: 30 ISSN: 1558-1497 ISO Abbreviation: Neurobiol. Aging Publication Date: 2009 Apr |
Date Detail:
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Created Date: 2009-03-16 Completed Date: 2009-06-22 Revised Date: 2013-03-22 |
Medline Journal Info:
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Nlm Unique ID: 8100437 Medline TA: Neurobiol Aging Country: United States |
Other Details:
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Languages: eng Pagination: 507-14 Citation Subset: IM |
Affiliation:
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Department of Psychology, University of Virginia, Charlottesville, VA 22904-4400, USA. Salthouse@virginia.edu |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adult Age of Onset Aging / physiology, psychology* Artifacts Cognition Disorders / diagnosis, epidemiology*, psychology* Cross-Sectional Studies Data Interpretation, Statistical Early Diagnosis Female Humans Learning / physiology Longitudinal Studies Male Memory Disorders / diagnosis, epidemiology*, psychology* Middle Aged Neuropsychological Tests / standards* Reproducibility of Results |
| Grant Support | |
ID/Acronym/Agency:
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R37 AG024270/AG/NIA NIH HHS; R37 AG024270-04/AG/NIA NIH HHS; R37AG024270/AG/NIA NIH HHS |
| Comments/Corrections | |
Comment In:
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Neurobiol Aging. 2009 Apr;30(4):528-9; discussion 530-33
[PMID:
19231029
]
Neurobiol Aging. 2009 Apr;30(4):515-20; discussion 530-33 [PMID: 19231030 ] Neurobiol Aging. 2009 Apr;30(4):521-4; discussion 530-3 [PMID: 19285194 ] Neurobiol Aging. 2009 Apr;30(4):525-7; discussion 530-3 [PMID: 19237224 ] |
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