| When the darker eye has the smaller pupil. | |
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MedLine Citation:
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PMID: 12825064 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Waardenburg and congenital Horner syndromes are both recognized causes of congenital hypochromic iris heterochromia. Each has been linked to disruptions in the pathway of tyrosinase induction, thus leading to a deficiency in melanin production of the iris. These syndromes must be considered in the differential diagnosis of a patient presenting with heterochromia iridis. We present the case of a 20-month old boy afflicted with both congenital Horner syndrome and Waardenburg syndrome, type II. In contrast to the more common presentation of congenital Horner syndrome, the affected iris in this case was the darker of the two because of the effects of the concomitant Waardenburg syndrome on the contralateral iris pigmentation. We are unaware of any other cases presenting with both Horner and Waardenburg syndromes and believe that this case serves as an excellent opportunity to briefly review the pathophysiology involved with these disorders. |
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Authors:
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David H Wallis; David B Granet; Leah Levi |
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Publication Detail:
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Type: Case Reports; Journal Article; Review |
Journal Detail:
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Title: Journal of AAPOS : the official publication of the American Association for Pediatric Ophthalmology and Strabismus / American Association for Pediatric Ophthalmology and Strabismus Volume: 7 ISSN: 1091-8531 ISO Abbreviation: J AAPOS Publication Date: 2003 Jun |
Date Detail:
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Created Date: 2003-06-25 Completed Date: 2003-10-02 Revised Date: 2006-04-21 |
Medline Journal Info:
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Nlm Unique ID: 9710011 Medline TA: J AAPOS Country: United States |
Other Details:
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Languages: eng Pagination: 215-6 Citation Subset: IM |
Affiliation:
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The Santa Monica UCLA Family Practice Residency Program, University of California, San Diego, La Jolla, CA, USA. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Anisocoria
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etiology* Eye Color* Horner Syndrome / complications*, congenital, pathology*, physiopathology Humans Infant Male Pupil* Waardenburg's Syndrome / complications*, pathology*, physiopathology |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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