Document Detail

When birth comes early: effects on nephrogenesis.
MedLine Citation:
PMID:  23279726     Owner:  NLM     Status:  Publisher    
Preterm birth is defined as birth prior to 37 completed weeks of gestation and comprises 9.6% of total births worldwide(1) . Preterm birth can be further sub-classified into near term (birth at 34 - 37 weeks gestation), moderately preterm (birth between 32 and 33 weeks of gestation), very preterm (birth between 28 and 31 weeks gestation) and extremely preterm (birth < 28 weeks of gestation). The survival of neonates after preterm birth has improved dramatically over recent decades, with babies born as young as 25 weeks gestation now having up to an 80% chance of survival(2) . Preterm birth has the potential for deleterious developmental programming, and the kidney is particularly vulnerable. Nephrogenesis normally ceases prior to term birth and any impact on nephron number at the beginning of life may have adverse consequences for life-long renal health(3) . In the human, the first nephrons are formed by 9 weeks of gestation and nephrogenesis is completed between 32 to 36 weeks gestation(4) . The majority of nephrons are formed in the third trimester of pregnancy at the time when preterm infants are being delivered. Emerging epidemiological studies have linked preterm birth with altered renal function in childhood and adulthood(5) . In addition, there are a number of studies linking preterm birth with an increase in blood pressure later in life(6,7) .
M Jane Black; Megan R Sutherland; Lina Gubhaju; Alison L Kent; Jane E Dahlstrom; Lynette Moore
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-12-28
Journal Detail:
Title:  Nephrology (Carlton, Vic.)     Volume:  -     ISSN:  1440-1797     ISO Abbreviation:  Nephrology (Carlton)     Publication Date:  2012 Dec 
Date Detail:
Created Date:  2013-1-2     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9615568     Medline TA:  Nephrology (Carlton)     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
© 2012 The Authors. Nephrology © 2012 Asian Pacific Society of Nephrology.
Department of Anatomy and Developmental Biology, Monash University, Clayton, Victoria, Australia.
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