Document Detail


When are fetuses and young children most susceptible to soil metal concentrations of arsenic, lead and mercury?
MedLine Citation:
PMID:  22749212     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
This study was designed to analyze when, during pregnancy and early childhood, the association between soil metal concentrations of arsenic (As), lead (Pb) and mercury (Hg) and the outcome of intellectual disability (ID) is statistically significant. Using cluster analysis, we identified ten areas of land that contained a cluster of ID and areas of average risk for ID. We analyzed soil for As, Pb, and Hg and estimated the soil metal concentration at the residential sites where the woman and children lived during pregnancy and early childhood using a Bayesian Kriging model. Arsenic concentrations were associated with ID during the first trimester of pregnancy and Hg was associated with ID early in pregnancy and the first two years of childhood. The covariates that remained in the final models were also temporally associated with ID.
Authors:
Suzanne McDermott; Weichao Bao; C Marjorie Aelion; Bo Cai; Andrew Lawson
Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural     Date:  2012-06-13
Journal Detail:
Title:  Spatial and spatio-temporal epidemiology     Volume:  3     ISSN:  1877-5853     ISO Abbreviation:  Spat Spatiotemporal Epidemiol     Publication Date:  2012 Sep 
Date Detail:
Created Date:  2012-07-03     Completed Date:  2013-02-11     Revised Date:  2013-09-03    
Medline Journal Info:
Nlm Unique ID:  101516571     Medline TA:  Spat Spatiotemporal Epidemiol     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  265-72     Citation Subset:  IM    
Copyright Information:
Copyright © 2012 Elsevier Ltd. All rights reserved.
Affiliation:
University of South Carolina, School of Medicine, Department of Family and Preventive Medicine, 3209 Colonial Drive Columbia, SC 29203, USA. suzanne.mcdermott@uscmed.sc.edu
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MeSH Terms
Descriptor/Qualifier:
Arsenic / adverse effects,  analysis*
Bayes Theorem
Child
Child, Preschool
Cluster Analysis
Cohort Studies
Environmental Exposure / adverse effects*
Female
Fetus / drug effects*
Humans
Intellectual Disability / etiology*
Lead / adverse effects,  analysis*
Maternal Exposure / adverse effects
Mercury / adverse effects,  analysis*
Pregnancy
Retrospective Studies
Soil Pollutants / adverse effects,  analysis*
Spatial Analysis
Grant Support
ID/Acronym/Agency:
R01 ES012895/ES/NIEHS NIH HHS; R01 ES012895-01A1/ES/NIEHS NIH HHS
Chemical
Reg. No./Substance:
0/Soil Pollutants; 7439-92-1/Lead; 7439-97-6/Mercury; 7440-38-2/Arsenic
Comments/Corrections

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