| When are fetuses and young children most susceptible to soil metal concentrations of arsenic, lead and mercury? | |
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MedLine Citation:
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PMID: 22749212 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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This study was designed to analyze when, during pregnancy and early childhood, the association between soil metal concentrations of arsenic (As), lead (Pb) and mercury (Hg) and the outcome of intellectual disability (ID) is statistically significant. Using cluster analysis, we identified ten areas of land that contained a cluster of ID and areas of average risk for ID. We analyzed soil for As, Pb, and Hg and estimated the soil metal concentration at the residential sites where the woman and children lived during pregnancy and early childhood using a Bayesian Kriging model. Arsenic concentrations were associated with ID during the first trimester of pregnancy and Hg was associated with ID early in pregnancy and the first two years of childhood. The covariates that remained in the final models were also temporally associated with ID. |
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Authors:
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Suzanne McDermott; Weichao Bao; C Marjorie Aelion; Bo Cai; Andrew Lawson |
Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural Date: 2012-06-13 |
Journal Detail:
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Title: Spatial and spatio-temporal epidemiology Volume: 3 ISSN: 1877-5853 ISO Abbreviation: Spat Spatiotemporal Epidemiol Publication Date: 2012 Sep |
Date Detail:
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Created Date: 2012-07-03 Completed Date: 2013-02-11 Revised Date: 2013-04-16 |
Medline Journal Info:
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Nlm Unique ID: 101516571 Medline TA: Spat Spatiotemporal Epidemiol Country: Netherlands |
Other Details:
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Languages: eng Pagination: 265-72 Citation Subset: IM |
Copyright Information:
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Copyright © 2012 Elsevier Ltd. All rights reserved. |
Affiliation:
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University of South Carolina, School of Medicine, Department of Family and Preventive Medicine, 3209 Colonial Drive Columbia, SC 29203, USA. suzanne.mcdermott@uscmed.sc.edu |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Arsenic
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adverse effects,
analysis* Bayes Theorem Child Child, Preschool Cluster Analysis Cohort Studies Environmental Exposure / adverse effects* Female Fetus / drug effects* Humans Intellectual Disability / etiology* Lead / adverse effects, analysis* Maternal Exposure / adverse effects Mercury / adverse effects, analysis* Pregnancy Retrospective Studies Soil Pollutants / adverse effects, analysis* Spatial Analysis |
| Grant Support | |
ID/Acronym/Agency:
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R01 ES012895-01A1/ES/NIEHS NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Soil Pollutants; 7439-92-1/Lead; 7439-97-6/Mercury; 7440-38-2/Arsenic |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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