Document Detail


When the air hits your brain: cerebral autoregulation of brain oxygenation during aerobic exercise allows transient hyperoxygenation: case report.
MedLine Citation:
PMID:  20644380     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
OBJECTIVE: Cerebral autoregulation maintains a relatively stable cerebral blood flow over a range of perfusion pressures. During exercise, regional cerebral blood flow may be elevated in particular areas of the brain. This case report presents the impact of aerobic exercise on intracranially measured pressure and brain tissue oxygenation in an adult human.
CLINCIAL PRESENTATION: A 30-year-old man with idiopathic intracranial hypertension treated with cerebrospinal fluid diversion was monitored with a Licox intracranial brain oxygen and pressure monitor (Integra NeuroSciences Corporation, Plainsboro, New Jersey) for refractory nonpostural headaches exacerbated after exercise. He performed trials of running and bicycling to provoke his headaches. The patient's mean intracranial pressure remained stable during exercise despite elevated cerebral perfusion pressures. Regional cerebral oxygen tension levels were strictly regulated to a level of approximately 39 mm Hg during steady state aerobic exercise, with transient increases up to 90 mm Hg at the onset and termination of activity.
CONCLUSION: Our results suggest that cerebral autoregulation appears to maintain constant cerebral oxygen tension during exercise. Further, we note transient cerebral hyperoxygenation at the onset of exercise as autoregulation "turns on" and at the termination of exercise. We present a quantitative interpretation of the post-exercise hyperoxygenation phase based on Fick's principle. We are the first to demonstrate cortical hyperoxygenation in a human breathing natural air without oxygen supplementation.
Authors:
Robert J Bollo; Susan C Williams; Charles S Peskin; Uzma Samadani
Publication Detail:
Type:  Case Reports; Journal Article    
Journal Detail:
Title:  Neurosurgery     Volume:  67     ISSN:  1524-4040     ISO Abbreviation:  Neurosurgery     Publication Date:  2010 Aug 
Date Detail:
Created Date:  2010-07-20     Completed Date:  2011-01-21     Revised Date:  2013-07-15    
Medline Journal Info:
Nlm Unique ID:  7802914     Medline TA:  Neurosurgery     Country:  United States    
Other Details:
Languages:  eng     Pagination:  E507-9     Citation Subset:  IM    
Affiliation:
Department of Neurosurgery, New York University School of Medicine and NYU Langone Medical Center, and Division of Neurosurgery, New York Harbor Healthcare System Manhattan Veterans Hospital, New York, New York, USA.
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MeSH Terms
Descriptor/Qualifier:
Adult
Bicycling / physiology
Brain / physiology*
Brain Chemistry / physiology*
Cerebrovascular Circulation
Exercise / physiology*
Headache / etiology
Homeostasis / physiology*
Humans
Hyperoxia / etiology*
Intracranial Hypertension / complications*,  physiopathology,  surgery
Intracranial Pressure / physiology
Male
Neurosurgical Procedures
Oxygen Consumption / physiology*
Running / physiology
Tomography, X-Ray Computed
Vision Disorders / etiology

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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