Document Detail

Wheel running prevents the accumulation of monounsaturated fatty acids in the liver of ovariectomized mice by attenuating changes in SCD-1 content.
MedLine Citation:
PMID:  22026420     Owner:  NLM     Status:  MEDLINE    
Decreases in female sex steroids enhance the accumulation of visceral fat mass, leading to a predisposition to developing metabolic diseases. The purpose of this study was to determine whether loss of ovarian function alters the amount and (or) the fatty acid (FA) composition of triacylglycerol (TAG) levels in the liver of ovary-intact (SHAM) or ovariectomized (OVX) mice. We also sought to determine whether voluntary wheel running could attenuate the associated changes in the liver. Twenty-two C57/BL6 female mice were divided into 2 groups (SHAM, OVX) and were then subdivided into sedentary and exercising groups (SHAM-Sed, SHAM-Ex, OVX-Sed, OVX-Ex). Visceral fat mass significantly increased in the OVX-Sed animals; however, the effect was attenuated in the OVX-Ex animals. Total hepatic TAG content did not significantly increase in the OVX-Sed animals; however, SHAM-Ex and OVX-Ex animals demonstrated significant decreases in TAG levels. A significant increase in the FA desaturase index (18:1/18:0 and 16:1/16:0) was detected in the OVX-Sed animals compared with all other groups, which corresponded to increases in stearoyl-CoA desaturase (SCD-1) content. These results indicate that loss of ovarian function alters FA composition of hepatic TAG mediated by increases in SCD-1. These data indicate that female sex steroids influence lipid metabolism in the liver and provide important insight concerning the influence of exercise on hepatic function.
Kathryn C Jackson; Lindsay M Wohlers; Ana P Valencia; Michelle Cilenti; Sarah J Borengasser; John P Thyfault; Espen E Spangenburg
Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.     Date:  2011-10-25
Journal Detail:
Title:  Applied physiology, nutrition, and metabolism = Physiologie appliquée, nutrition et métabolisme     Volume:  36     ISSN:  1715-5312     ISO Abbreviation:  Appl Physiol Nutr Metab     Publication Date:  2011 Dec 
Date Detail:
Created Date:  2011-12-02     Completed Date:  2012-03-08     Revised Date:  2012-05-24    
Medline Journal Info:
Nlm Unique ID:  101264333     Medline TA:  Appl Physiol Nutr Metab     Country:  Canada    
Other Details:
Languages:  eng     Pagination:  798-810     Citation Subset:  IM    
Department of Kinesiology, School of Public Health, University of Maryland, College Park, MD 21045, USA.
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MeSH Terms
Behavior, Animal
Diacylglycerol O-Acyltransferase / genetics,  metabolism
Diglycerides / metabolism
Fatty Acids, Monounsaturated / metabolism*
Gene Expression Regulation, Enzymologic
Hyperglycemia / etiology
Intra-Abdominal Fat / pathology
Liver / metabolism*
Menopause / blood,  metabolism*
Mice, Inbred C57BL
Motor Activity*
Ovariectomy / adverse effects*
Overweight / prevention & control
RNA, Messenger / metabolism
Stearoyl-CoA Desaturase / metabolism*
Triglycerides / metabolism
Grant Support
Reg. No./Substance:
0/Diglycerides; 0/Fatty Acids, Monounsaturated; 0/RNA, Messenger; 0/Triglycerides; EC protein, mouse; EC Desaturase; EC protein, mouse; EC O-Acyltransferase

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