Document Detail


Wheel running can accelerate or delay extinction of conditioned place preference for cocaine in male C57BL/6J mice, depending on timing of wheel access.
MedLine Citation:
PMID:  21864322     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Aerobic exercise may represent a useful intervention for drug abuse in predisposed individuals. Exercise increases plasticity in the brain that could be used to reverse learned drug associations. Previous studies have reported that exposing mice to a complex environment including running wheels after drug conditioning abolishes conditioned place preference (CPP) for cocaine, whereas running can enhance CPP when administered before conditioning. The purpose of the present study was to test the hypothesis that timing of exercise relative to conditioning has opposing effects on cocaine CPP. Male C57BL/6J mice experienced 30 days of running or sedentary treatments either before or after cocaine conditioning. Control animals always received saline and never cocaine, but otherwise underwent the same conditioning and exercise treatments. Animals were given bromodeoxyuridine injections at the onset of conditioning or exercise, and euthanized at the end of the study to quantify survival of new neurons in the hippocampus as a marker of plasticity. Wheel running accelerated extinction of CPP when running occurred entirely after drug conditioning, whereas running delayed extinction when administered before conditioning. A single conditioning day after running was sufficient to abolish the accelerated extinction observed when all conditioning preceded running. Running approximately doubled adult hippocampal neurogenesis, whereas cocaine had no effect. These results suggest that exercise-induced plasticity can facilitate learning that context is no longer associated with drug. However, if drug exposure occurs after exercise, running-induced plasticity may strengthen drug associations. The results provide insights into the interaction between exercise and drug conditioning that could have implications for drug abuse treatments.
Authors:
Martina L Mustroph; Derrick J Stobaugh; Daniel S Miller; Erin K DeYoung; Justin S Rhodes
Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural     Date:  2011-08-22
Journal Detail:
Title:  The European journal of neuroscience     Volume:  34     ISSN:  1460-9568     ISO Abbreviation:  Eur. J. Neurosci.     Publication Date:  2011 Oct 
Date Detail:
Created Date:  2011-10-04     Completed Date:  2012-02-10     Revised Date:  2014-09-13    
Medline Journal Info:
Nlm Unique ID:  8918110     Medline TA:  Eur J Neurosci     Country:  France    
Other Details:
Languages:  eng     Pagination:  1161-9     Citation Subset:  IM    
Copyright Information:
© 2011 The Authors. European Journal of Neuroscience © 2011 Federation of European Neuroscience Societies and Blackwell Publishing Ltd.
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MeSH Terms
Descriptor/Qualifier:
Animals
Behavior, Animal / drug effects,  physiology*
Cocaine / pharmacology*
Conditioning, Operant / drug effects
Dopamine Uptake Inhibitors / pharmacology*
Extinction, Psychological / drug effects,  physiology*
Hippocampus / drug effects,  physiology
Male
Mice
Mice, Inbred C57BL
Neurogenesis / drug effects,  physiology
Physical Conditioning, Animal / physiology*
Time Factors
Grant Support
ID/Acronym/Agency:
DA027487/DA/NIDA NIH HHS; MH 083807/MH/NIMH NIH HHS; R01 DA027487/DA/NIDA NIH HHS; R01 DA027487-01/DA/NIDA NIH HHS; R01 DA027487-02/DA/NIDA NIH HHS; R01 DA027487-03/DA/NIDA NIH HHS; R01 MH083807/MH/NIMH NIH HHS; R01 MH083807-01A1/MH/NIMH NIH HHS; R01 MH083807-02/MH/NIMH NIH HHS; R01 MH083807-03/MH/NIMH NIH HHS; R01 MH083807-04/MH/NIMH NIH HHS
Chemical
Reg. No./Substance:
0/Dopamine Uptake Inhibitors; I5Y540LHVR/Cocaine
Comments/Corrections

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