Document Detail


Wheel running as a predictor of cocaine self-administration and reinstatement in female rats.
MedLine Citation:
PMID:  16337260     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Avidity for behaviors mediated by nondrug rewards, such as novelty seeking or intake of sweets or fats, is predictive of enhanced vulnerability to the locomotor-activating and rewarding effects of drugs of abuse. The purpose of the present study was to determine whether avidity for wheel running was predictive of subsequent cocaine-induced locomotor activity, cocaine self-administration, and cocaine-seeking behavior in rats. Rats with high (HiR) and low (LoR) levels of wheel running were selected from an outbred sample of Wistar rats. These rats were first tested for their locomotor response to an acute injection of cocaine (10 mg/kg, i.p.). Subsequently, a multi-phase self-administration procedure was used to examine the effect of wheel running on the maintenance, extinction, and cocaine-induced reinstatement of cocaine-seeking behavior in HiR and LoR rats. The results indicate no significant differences between HiR and LoR rats in the cocaine-induced stimulation of locomotor activity. During maintenance, HiR rats self-administered more cocaine than LoR rats. While there were no group differences in saline self-administration behavior during extinction, HiR rats showed higher cocaine-induced reinstatement than LoR rats. Rats that were previously high responders to novelty (day 1 in locomotor track) also showed significantly higher reinstatement than low novelty responders. These results suggest that a propensity for wheel running is associated with increased vulnerability for cocaine self-administration and reinstatement and that HiR rats are more motivated than LoR rats to seek cocaine.
Authors:
Erin B Larson; Marilyn E Carroll
Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural     Date:  2005-12-06
Journal Detail:
Title:  Pharmacology, biochemistry, and behavior     Volume:  82     ISSN:  0091-3057     ISO Abbreviation:  Pharmacol. Biochem. Behav.     Publication Date:  2005 Nov 
Date Detail:
Created Date:  2005-12-26     Completed Date:  2006-03-02     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  0367050     Medline TA:  Pharmacol Biochem Behav     Country:  United States    
Other Details:
Languages:  eng     Pagination:  590-600     Citation Subset:  IM    
Affiliation:
Graduate Program in Neuroscience, University of Minnesota, MMC 392, Minneapolis, MN 55455, United States. larso323@umn.edu
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MeSH Terms
Descriptor/Qualifier:
Animals
Cocaine / administration & dosage*
Female
Motivation
Motor Activity / drug effects
Physical Conditioning, Animal*
Rats
Rats, Wistar
Grant Support
ID/Acronym/Agency:
K05 DA15267/DA/NIDA NIH HHS; R01 DA03240/DA/NIDA NIH HHS
Chemical
Reg. No./Substance:
50-36-2/Cocaine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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