Document Detail


Wheat threshing dust--a "new allergen" in April-May nasobronchial allergy.
MedLine Citation:
PMID:  8979566     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
OBJECTIVE: To identify the allergen(s) responsible for mid April-mid May nasobronchial allergy seen in North India. DESIGN: Case control study. SETTING: Children living in and around Chandigarh (urban, rural). SUBJECTS: 39 children suffering from wheat harvest period (mid April-mid May) respiratory allergy along with randomly selected controls. METHODS: Aerobiological surveys were done from March to June for identification of prevailing allergens for performing allergy tests. Patients were subjected to skin tests (ST), nasal provocation tests (NPT) and bronchial provocation tests (BPT) with extracts prepared from identified pollens and fungal spores. Specific IgE (SIgE) was assayed by ELISA and comparison between pre-season, season and post-season values made. RESULTS: 81% patients had ST positive to antigen of wheat threshing dust (WTD), 30% to fungal antigens, 14% to wheat dust antigens and none to the wheat plant (WP) antigens. Nasal provocation test and bronchial provocation tests were also positive to WTD in 80% and 66% patients, respectively. WTD SIgE was demonstrated in 77% of ST positive patients. CONCLUSIONS: These in vivo and in vitro tests confirm wheat threshing dust as a major causative inhalant allergen for the April-May nasobronchial allergy; in addition, fungal allergens also play a role in 1/3rd of these patients.
Authors:
S Lavasa; L Kumar; S C Kaushal; N K Ganguli
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Indian pediatrics     Volume:  33     ISSN:  0019-6061     ISO Abbreviation:  Indian Pediatr     Publication Date:  1996 Jul 
Date Detail:
Created Date:  1997-02-05     Completed Date:  1997-02-05     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  2985062R     Medline TA:  Indian Pediatr     Country:  INDIA    
Other Details:
Languages:  eng     Pagination:  566-70     Citation Subset:  IM    
Affiliation:
Department of Pediatrics, Postgraduate Institute of Medical Education and Research, Chandigarh.
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MeSH Terms
Descriptor/Qualifier:
Adolescent
Agriculture*
Analysis of Variance
Case-Control Studies
Child
Dust / adverse effects*
Humans
India / epidemiology
Respiratory Hypersensitivity / epidemiology*,  immunology,  microbiology
Seasons*
Triticum / adverse effects*
Chemical
Reg. No./Substance:
0/Dust

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