| Wheat-starch-based gluten-free products in the treatment of newly detected coeliac disease: prospective and randomized study. | |
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MedLine Citation:
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PMID: 12622768 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND: The safety of wheat-starch-based gluten-free products in the treatment of coeliac disease is debatable. Prospective studies are lacking. AIM: : To compare the clinical, histological and serological response to a wheat-starch-based or natural gluten-free diet in patients with newly detected coeliac disease. METHODS: Fifty-seven consecutive adults with untreated coeliac disease were randomized to a wheat-starch-based or natural gluten-free diet. Clinical response, small bowel mucosal morphology, CD3+, alphabeta+ and gammadelta+ intra-epithelial lymphocytes, mucosal human leucocyte antigen-DR expression and serum endomysial, transglutaminase and gliadin antibodies were investigated before and 12 months after the introduction of the gluten-free diet. Quality of life measurements were performed by standardized questionnaires and the bone mineral density was analysed. RESULTS: In both groups, abdominal symptoms were alleviated equally by a strict diet. There were no differences between the groups in mucosal morphology, the density of intra-epithelial lymphocytes, serum antibodies, bone mineral density or quality of life tests at the end of the study. Four patients on a natural gluten-free diet and two on a wheat-starch-based gluten-free diet had dietary lapses; as a result, inadequate mucosal, serological and clinical recovery was observed. CONCLUSIONS: The dietary response to a wheat-starch-based gluten-free diet was as good as that to a natural gluten-free diet in patients with newly detected coeliac disease. |
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Authors:
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M Peräaho; K Kaukinen; K Paasikivi; H Sievänen; S Lohiniemi; M Mäki; P Collin |
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Publication Detail:
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Type: Clinical Trial; Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Alimentary pharmacology & therapeutics Volume: 17 ISSN: 0269-2813 ISO Abbreviation: Aliment. Pharmacol. Ther. Publication Date: 2003 Feb |
Date Detail:
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Created Date: 2003-03-07 Completed Date: 2003-04-28 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 8707234 Medline TA: Aliment Pharmacol Ther Country: England |
Other Details:
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Languages: eng Pagination: 587-94 Citation Subset: IM |
Affiliation:
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Department of Medicine, Tampere University Hospital, Tampere, Finland. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adult Aged Bone Density Celiac Disease / blood, diet therapy*, pathology Enzyme-Linked Immunosorbent Assay Female Health Status Humans Immunoglobulin A / blood Male Middle Aged Prospective Studies Quality of Life Starch / administration & dosage* Triticum* |
| Chemical | |
Reg. No./Substance:
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0/Immunoglobulin A; 9005-25-8/Starch |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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