Document Detail

Wheat germ supplementation of a low vitamin E diet in rats affords effective antioxidant protection in tissues.
MedLine Citation:
PMID:  18689553     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: Oxidative stress is implicated in the etiology of many diseases, but most of clinical trials failed to demonstrate beneficial effects of antioxidant supplementation. METHODS: In the present experiment, we assessed the mean-term effect of wheat germ supplementation, as a dietary source of vitamin E, on antioxidant protection in rat. RESULTS: Feeding rats a 20% wheat germ diet significantly increased plasma and liver vitamin E levels, compared to the low vitamin E basal diet. Concurrently, wheat germ diet consumption strongly decreased the susceptibility of heart and liver lipids to oxidation, as well as the plasma. Wheat germ feeding did not change triglycerides (TG) nor total cholesterol concentrations in plasma or liver, resulting in higher vitamin E/TG ratio compared to controls. Similar results were found with a diet in which wheat germ oil provided the same amount of vitamin E. CONCLUSIONS: Wheat germ appears thus very effective to improve antioxidant defense status, especially in tissues, irrespective of modifications of lipids status.
Fanny Leenhardt; Anthony Fardet; Bernard Lyan; Elyett Gueux; Edmond Rock; Andrzej Mazur; Elisabeth Chanliaud; Christian Demigné; Christian Rémésy
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Journal of the American College of Nutrition     Volume:  27     ISSN:  1541-1087     ISO Abbreviation:  J Am Coll Nutr     Publication Date:  2008 Apr 
Date Detail:
Created Date:  2008-08-11     Completed Date:  2008-11-10     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8215879     Medline TA:  J Am Coll Nutr     Country:  United States    
Other Details:
Languages:  eng     Pagination:  222-8     Citation Subset:  IM    
INRA Clermont/Theix, Unité de Nutrition Humaine, F-63122 St-Genes-Champanelle, France.
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MeSH Terms
Antioxidants / pharmacology*
Cholesterol / blood
Liver / metabolism
Malondialdehyde / urine
Myocardium / metabolism
Oxidative Stress / drug effects,  physiology
Plant Oils / pharmacology*
Random Allocation
Rats, Wistar
Thiobarbituric Acid Reactive Substances / metabolism
Triglycerides / blood
Vitamin E / blood*
Vitamin E Deficiency / blood,  drug therapy,  urine
Reg. No./Substance:
0/Antioxidants; 0/Plant Oils; 0/Thiobarbituric Acid Reactive Substances; 0/Triglycerides; 1406-18-4/Vitamin E; 542-78-9/Malondialdehyde; 57-88-5/Cholesterol; 68917-73-7/wheat germ oil

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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