Document Detail

Wheat germ policosanol failed to lower plasma cholesterol in subjects with normal to mildly elevated cholesterol concentrations.
MedLine Citation:
PMID:  15375787     Owner:  NLM     Status:  MEDLINE    
Sugar cane policosanol, a mixture of long-chain primary alcohols (approximately 67% as octacosanol), has been reported to lower plasma low-density lipoprotein (LDL)-cholesterol. We investigated the effect of wheat germ policosanol (WGP) on plasma lipid profiles in 58 adults (30 men and 28 women, aged 49 +/- 11 years) with normal to mildly elevated plasma cholesterol concentrations in a double-blind, randomized, parallel placebo-controlled study. Subjects consumed chocolate pellets with or without 20 mg/d WGP for 4 weeks. Plasma lipid concentrations, routine blood chemistry and hematology were determined at the start and the end of the study. The initial plasma total, LDL-cholesterol, high-density lipoprotein (HDL)-cholesterol, and triacylglycerol concentrations in the WGP and the control groups were identical. Over the 4 weeks, neither the WGP nor the control treatment significantly changed plasma total cholesterol, LDL- and HDL-cholesterol, or triacylglycerol concentrations when compared to baseline values. In addition, there was no significant difference in plasma lipid profiles between the WGP and the control groups at the end of the study. WGP did not result in any adverse effects as indicated by plasma activities of L-gamma-glutamyltransferase (gamma-GT), ALT, AST, bilirubin concentrations, and blood cell profiles. Chemical analysis showed that WGP consists of 8% hexacosanol, 67% octacosanol, 12% triacosanol, and 13% other long-chain alcohols, which is similar to the composition of sugar cane policosanol. In conclusion, WGP at 20 mg/d had no beneficial effects on blood lipid profiles. It therefore seems unlikely that the long chain (C24-34) alcohols have any cholesterol-lowering activity.
Yuguang Lin; Mike Rudrum; Reggy P J van der Wielen; Elke A Trautwein; Gerald McNeill; Aafje Sierksma; Gert W Meijer
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Publication Detail:
Type:  Clinical Trial; Journal Article; Randomized Controlled Trial    
Journal Detail:
Title:  Metabolism: clinical and experimental     Volume:  53     ISSN:  0026-0495     ISO Abbreviation:  Metab. Clin. Exp.     Publication Date:  2004 Oct 
Date Detail:
Created Date:  2004-09-17     Completed Date:  2004-11-09     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  0375267     Medline TA:  Metabolism     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1309-14     Citation Subset:  IM    
Unilever Health Institute, Unilever R&D, Vlaardingen, The Netherlands.
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MeSH Terms
Anticholesteremic Agents / therapeutic use*
Bilirubin / blood
Cholesterol / blood*
Dietary Fats / pharmacology
Double-Blind Method
Energy Metabolism / drug effects
Fatty Alcohols / pharmacology,  therapeutic use*
Hypercholesterolemia / blood*,  drug therapy*
Lipids / blood
Middle Aged
Triticum / chemistry*
Reg. No./Substance:
0/Anticholesteremic Agents; 0/Dietary Fats; 0/Fatty Alcohols; 0/Lipids; 142583-61-7/policosanol; 57-88-5/Cholesterol; 635-65-4/Bilirubin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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