Document Detail

Wheat fibre, lactulose and rectal mucosal proliferation in individuals with a family history of colorectal cancer.
MedLine Citation:
PMID:  7827943     Owner:  NLM     Status:  MEDLINE    
In a single-blind study 38 individuals at increased risk of developing colorectal cancer because of a family history of the disease were randomized to take 10.5 g wheat fibre (Trifyba) or 60 ml lactulose daily for 12 weeks. Rectal biopsies were taken before and after treatment and rectal mucosal proliferation was measured by the crypt cell production rate (CCPR). The mean(s.d.) CCPR was significantly lower in those taking wheat fibre after 12 weeks (7.2(3.4) crypt cells per crypt per h) compared both with values obtained before treatment with wheat fibre (10.2(5.1) crypt cells per crypt per h; P = 0.02) and after treatment with lactulose (9.4(3.8) crypt cells per crypt per h; P = 0.05). Proliferation in the lactulose group was not significantly different at 12 weeks compared with the value obtained before treatment. This study confirms an antiproliferative effect of wheat fibre in a group of high-risk individuals.
P S Rooney; L M Hunt; P A Clarke; K A Gifford; J D Hardcastle; N C Armitage
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Publication Detail:
Type:  Clinical Trial; Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  The British journal of surgery     Volume:  81     ISSN:  0007-1323     ISO Abbreviation:  Br J Surg     Publication Date:  1994 Dec 
Date Detail:
Created Date:  1995-02-23     Completed Date:  1995-02-23     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0372553     Medline TA:  Br J Surg     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  1792-4     Citation Subset:  AIM; IM    
Department of Surgery, University Hospital, Queen's Medical Centre, Nottingham, UK.
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MeSH Terms
Cell Transformation, Neoplastic
Colorectal Neoplasms / genetics,  pathology,  prevention & control*
Dietary Fiber*
Hydrogen-Ion Concentration
Intestinal Mucosa / pathology
Lactulose / administration & dosage*
Rectum / pathology
Risk Factors
Single-Blind Method
Reg. No./Substance:

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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