Document Detail


What's taking so long? S-phase entry from quiescence versus proliferation.
MedLine Citation:
PMID:  17637736     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
There is a short window in the mammalian cell cycle during which cells can respond to extracellular cues by withdrawing temporarily from the cell cycle. When these cells re-enter the cell cycle, they require several extra hours in the G1 phase before they replicate their DNA compared with their cycling counterparts. More than 20 years after this initial observation, we still do not understand what is taking so long.
Authors:
Hilary A Coller
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Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, Non-U.S. Gov't; Review    
Journal Detail:
Title:  Nature reviews. Molecular cell biology     Volume:  8     ISSN:  1471-0072     ISO Abbreviation:  Nat. Rev. Mol. Cell Biol.     Publication Date:  2007 Aug 
Date Detail:
Created Date:  2007-07-23     Completed Date:  2007-09-26     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  100962782     Medline TA:  Nat Rev Mol Cell Biol     Country:  England    
Other Details:
Languages:  eng     Pagination:  667-70     Citation Subset:  IM    
Affiliation:
Department of Molecular Biology, Lewis Thomas Laboratory, Room 140, Princeton University, Princeton, New Jersey 08544-1014, USA. hcoller@princeton.edu
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MeSH Terms
Descriptor/Qualifier:
Animals
DNA Replication / physiology*
G1 Phase / physiology*
Humans
S Phase / physiology*
Time Factors

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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