| What and when to "want"? Amygdala-based focusing of incentive salience upon sugar and sex. | |
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MedLine Citation:
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PMID: 22167254 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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RATIONALE: Amygdala-related circuitry helps translate learned Pavlovian associations into appetitive and aversive motivation, especially upon subsequent encounters with cues. OBJECTIVES: We asked whether μ-opioid stimulation via microinjections of the specific agonist D-Ala(2), N-MePhe(4), Gly-ol)-enkephalin (DAMGO) in central nucleus of amygdala (CeA), or the adjacent basolateral amygdala (BLA) would magnify sucrose or sex "wanting", guided by available cues. MATERIALS AND METHODS: CeA or BLA DAMGO enhancement of cue-triggered "wanting" was assessed using Pavlovian to instrumental transfer (PIT). Unconditioned food "wanting" was measured via intake, and male sexual "wanting" for an estrous female was measured in a sexual approach test. Sucrose hedonic taste "liking" was measured in a taste reactivity test. RESULTS: CeA (but not BLA) DAMGO increased the intensity of phasic peaks in instrumental sucrose seeking stimulated by Pavlovian cues over precue levels in PIT, while suppressing seeking at other moments. CeA DAMGO also enhanced food intake, as well as sexual approach and investigation of an estrous female by males. DAMGO "wanting" enhancements were localized to CeA, as indicated by "Fos plume"-based anatomical maps for DAMGO causation of behavioral effects. Despite increasing "wanting", CeA DAMGO decreased the hedonic impact or "liking" for sucrose in a taste reactivity paradigm. CONCLUSIONS: CeA μ-opioid stimulation specifically enhances incentive salience, which is dynamically guided to food or sex by available cues. |
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Authors:
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Stephen V Mahler; Kent C Berridge |
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Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural Date: 2011-12-14 |
Journal Detail:
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Title: Psychopharmacology Volume: 221 ISSN: 1432-2072 ISO Abbreviation: Psychopharmacology (Berl.) Publication Date: 2012 Jun |
Date Detail:
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Created Date: 2012-05-14 Completed Date: 2012-11-26 Revised Date: 2013-04-16 |
Medline Journal Info:
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Nlm Unique ID: 7608025 Medline TA: Psychopharmacology (Berl) Country: Germany |
Other Details:
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Languages: eng Pagination: 407-26 Citation Subset: IM |
Affiliation:
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Department of Psychology, University of Michigan, Ann Arbor, MI, USA. mahler@musc.edu |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Amygdala
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drug effects,
metabolism* Analgesics, Opioid / pharmacology Animals Behavior, Animal / drug effects* Cues Eating / drug effects Enkephalin, Ala(2)-MePhe(4)-Gly(5)- / pharmacology* Estrus / physiology Female Male Rats Rats, Sprague-Dawley Receptors, Opioid, mu / agonists*, metabolism Sexual Behavior, Animal / drug effects Sucrose / administration & dosage |
| Grant Support | |
ID/Acronym/Agency:
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DA015188/DA/NIDA NIH HHS; DA021481/DA/NIDA NIH HHS; F31 DA021481/DA/NIDA NIH HHS; MH053649/MH/NIMH NIH HHS; R01 DA015188/DA/NIDA NIH HHS; R01 MH063649/MH/NIMH NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Analgesics, Opioid; 0/Receptors, Opioid, mu; 100929-53-1/Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; 57-50-1/Sucrose |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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