Document Detail


What and when to "want"? Amygdala-based focusing of incentive salience upon sugar and sex.
MedLine Citation:
PMID:  22167254     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
RATIONALE: Amygdala-related circuitry helps translate learned Pavlovian associations into appetitive and aversive motivation, especially upon subsequent encounters with cues.
OBJECTIVES: We asked whether μ-opioid stimulation via microinjections of the specific agonist D-Ala(2), N-MePhe(4), Gly-ol)-enkephalin (DAMGO) in central nucleus of amygdala (CeA), or the adjacent basolateral amygdala (BLA) would magnify sucrose or sex "wanting", guided by available cues.
MATERIALS AND METHODS: CeA or BLA DAMGO enhancement of cue-triggered "wanting" was assessed using Pavlovian to instrumental transfer (PIT). Unconditioned food "wanting" was measured via intake, and male sexual "wanting" for an estrous female was measured in a sexual approach test. Sucrose hedonic taste "liking" was measured in a taste reactivity test.
RESULTS: CeA (but not BLA) DAMGO increased the intensity of phasic peaks in instrumental sucrose seeking stimulated by Pavlovian cues over precue levels in PIT, while suppressing seeking at other moments. CeA DAMGO also enhanced food intake, as well as sexual approach and investigation of an estrous female by males. DAMGO "wanting" enhancements were localized to CeA, as indicated by "Fos plume"-based anatomical maps for DAMGO causation of behavioral effects. Despite increasing "wanting", CeA DAMGO decreased the hedonic impact or "liking" for sucrose in a taste reactivity paradigm.
CONCLUSIONS: CeA μ-opioid stimulation specifically enhances incentive salience, which is dynamically guided to food or sex by available cues.
Authors:
Stephen V Mahler; Kent C Berridge
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural     Date:  2011-12-14
Journal Detail:
Title:  Psychopharmacology     Volume:  221     ISSN:  1432-2072     ISO Abbreviation:  Psychopharmacology (Berl.)     Publication Date:  2012 Jun 
Date Detail:
Created Date:  2012-05-14     Completed Date:  2012-11-26     Revised Date:  2013-06-27    
Medline Journal Info:
Nlm Unique ID:  7608025     Medline TA:  Psychopharmacology (Berl)     Country:  Germany    
Other Details:
Languages:  eng     Pagination:  407-26     Citation Subset:  IM    
Affiliation:
Department of Psychology, University of Michigan, Ann Arbor, MI, USA. mahler@musc.edu
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MeSH Terms
Descriptor/Qualifier:
Amygdala / drug effects,  metabolism*
Analgesics, Opioid / pharmacology
Animals
Behavior, Animal / drug effects*
Cues
Eating / drug effects
Enkephalin, Ala(2)-MePhe(4)-Gly(5)- / pharmacology*
Estrus / physiology
Female
Male
Rats
Rats, Sprague-Dawley
Receptors, Opioid, mu / agonists*,  metabolism
Sexual Behavior, Animal / drug effects
Sucrose / administration & dosage
Grant Support
ID/Acronym/Agency:
DA015188/DA/NIDA NIH HHS; DA021481/DA/NIDA NIH HHS; F31 DA021481/DA/NIDA NIH HHS; MH053649/MH/NIMH NIH HHS; R01 DA015188/DA/NIDA NIH HHS; R01 MH063649/MH/NIMH NIH HHS
Chemical
Reg. No./Substance:
0/Analgesics, Opioid; 0/Receptors, Opioid, mu; 100929-53-1/Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; 57-50-1/Sucrose
Comments/Corrections

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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