| What we have learned regarding antibiotic therapy for the reduction of infant morbidity after preterm premature rupture of the membranes. | |
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MedLine Citation:
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PMID: 12889589 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Preterm premature rupture of the membranes (pPROM) is responsible for approximately one third of the over 450,000 preterm births occurring in the United States annually. In this manuscript, we summarize the outcomes and analyses related to the National Institute of Child Health and Human Development Maternal Fetal Medicine Units Network (NICHD-MFMU) network multicenter trial of antibiotics to reduce infant morbidity after pPROM. Based on evident reduction in gestational age dependent and infectious infant morbidity, we provide the rationale for aggressive intravenous and oral, broad spectrum Ampicillin/Amoxicillin, and Erythromycin therapy during conservative management of pPROM before 32 weeks' gestation. We further review the histopathologic correlates to pPROM, to antibiotic treatment, and to perinatal outcome, and discuss the relationships between maternal and neonatal cytokine levels intercellular adhesion molecule, and other clinical and plasma markers regarding perinatal morbidity. The use and limitations of ultrasound and vaginally collected amniotic fluid pulmonary maturity assessment are discussed. |
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Authors:
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Brian M Mercer; Robert L Goldenberg; Anita F Das; Gary R Thurnau; Robert W Bendon; Menachem Miodovnik; Risa D Ramsey; Yolanda A Rabello; |
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Publication Detail:
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Type: Journal Article; Research Support, U.S. Gov't, P.H.S.; Review |
Journal Detail:
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Title: Seminars in perinatology Volume: 27 ISSN: 0146-0005 ISO Abbreviation: Semin. Perinatol. Publication Date: 2003 Jun |
Date Detail:
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Created Date: 2003-07-31 Completed Date: 2003-11-10 Revised Date: 2007-11-15 |
Medline Journal Info:
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Nlm Unique ID: 7801132 Medline TA: Semin Perinatol Country: United States |
Other Details:
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Languages: eng Pagination: 217-30 Citation Subset: IM |
Affiliation:
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Department of Obstetrics and Gynecology, Case Western Reserve University, Cleveland, OH, USA. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Amoxicillin
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therapeutic use Ampicillin / therapeutic use Anti-Infective Agents / administration & dosage, therapeutic use* Drug Therapy, Combination Erythromycin / therapeutic use Female Fetal Membranes, Premature Rupture / mortality*, prevention & control* Gestational Age Humans Infant Mortality* Infant, Newborn Multicenter Studies as Topic National Institutes of Health (U.S.) Pregnancy Randomized Controlled Trials as Topic Treatment Outcome United States |
| Grant Support | |
ID/Acronym/Agency:
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M01-RR-000080/RR/NCRR NIH HHS; U10-HD-19897/HD/NICHD NIH HHS; U10-HD-21414/HD/NICHD NIH HHS; U10-HD-21434/HD/NICHD NIH HHS; U10-HD-27860/HD/NICHD NIH HHS; U10-HD-27861/HD/NICHD NIH HHS; U10-HD-27869/HD/NICHD NIH HHS; U10-HD-27883/HD/NICHD NIH HHS; U10-HD-27889/HD/NICHD NIH HHS; U10-HD-27905/HD/NICHD NIH HHS; U10-HD-27915/HD/NICHD NIH HHS; U10-HD-27917/HD/NICHD NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Anti-Infective Agents; 114-07-8/Erythromycin; 26787-78-0/Amoxicillin; 69-53-4/Ampicillin |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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