Document Detail


What we have learned regarding antibiotic therapy for the reduction of infant morbidity after preterm premature rupture of the membranes.
MedLine Citation:
PMID:  12889589     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Preterm premature rupture of the membranes (pPROM) is responsible for approximately one third of the over 450,000 preterm births occurring in the United States annually. In this manuscript, we summarize the outcomes and analyses related to the National Institute of Child Health and Human Development Maternal Fetal Medicine Units Network (NICHD-MFMU) network multicenter trial of antibiotics to reduce infant morbidity after pPROM. Based on evident reduction in gestational age dependent and infectious infant morbidity, we provide the rationale for aggressive intravenous and oral, broad spectrum Ampicillin/Amoxicillin, and Erythromycin therapy during conservative management of pPROM before 32 weeks' gestation. We further review the histopathologic correlates to pPROM, to antibiotic treatment, and to perinatal outcome, and discuss the relationships between maternal and neonatal cytokine levels intercellular adhesion molecule, and other clinical and plasma markers regarding perinatal morbidity. The use and limitations of ultrasound and vaginally collected amniotic fluid pulmonary maturity assessment are discussed.
Authors:
Brian M Mercer; Robert L Goldenberg; Anita F Das; Gary R Thurnau; Robert W Bendon; Menachem Miodovnik; Risa D Ramsey; Yolanda A Rabello;
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Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, P.H.S.; Review    
Journal Detail:
Title:  Seminars in perinatology     Volume:  27     ISSN:  0146-0005     ISO Abbreviation:  Semin. Perinatol.     Publication Date:  2003 Jun 
Date Detail:
Created Date:  2003-07-31     Completed Date:  2003-11-10     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  7801132     Medline TA:  Semin Perinatol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  217-30     Citation Subset:  IM    
Affiliation:
Department of Obstetrics and Gynecology, Case Western Reserve University, Cleveland, OH, USA.
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MeSH Terms
Descriptor/Qualifier:
Amoxicillin / therapeutic use
Ampicillin / therapeutic use
Anti-Infective Agents / administration & dosage,  therapeutic use*
Drug Therapy, Combination
Erythromycin / therapeutic use
Female
Fetal Membranes, Premature Rupture / mortality*,  prevention & control*
Gestational Age
Humans
Infant Mortality*
Infant, Newborn
Multicenter Studies as Topic
National Institutes of Health (U.S.)
Pregnancy
Randomized Controlled Trials as Topic
Treatment Outcome
United States
Grant Support
ID/Acronym/Agency:
M01-RR-000080/RR/NCRR NIH HHS; U10-HD-19897/HD/NICHD NIH HHS; U10-HD-21414/HD/NICHD NIH HHS; U10-HD-21434/HD/NICHD NIH HHS; U10-HD-27860/HD/NICHD NIH HHS; U10-HD-27861/HD/NICHD NIH HHS; U10-HD-27869/HD/NICHD NIH HHS; U10-HD-27883/HD/NICHD NIH HHS; U10-HD-27889/HD/NICHD NIH HHS; U10-HD-27905/HD/NICHD NIH HHS; U10-HD-27915/HD/NICHD NIH HHS; U10-HD-27917/HD/NICHD NIH HHS
Chemical
Reg. No./Substance:
0/Anti-Infective Agents; 114-07-8/Erythromycin; 26787-78-0/Amoxicillin; 69-53-4/Ampicillin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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