| What is type VI secretion doing in all those bugs? | |
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MedLine Citation:
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PMID: 20961764 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The identification of bacterial secretion systems capable of translocating substrates into eukaryotic cells via needle-like appendages has opened fruitful and exciting areas of microbial pathogenesis research. The recent discovery of the type VI secretion system (T6SS) was met with early speculation that it too acts as a 'needle' that pathogens aim at host cells. New reports demonstrate that certain T6SSs are potent mediators of interbacterial interactions. In light of these findings, we examined earlier data indicating its role in pathogenesis. We conclude that although T6S can, in rare instances, directly influence interactions with higher organisms, the broader physiological significance of the system is likely to provide defense against simple eukaryotic cells and other bacteria in the environment. The crucial role of T6S in bacterial interactions, along with its presence in many organisms relevant to disease, suggests that it might be a key determinant in the progression and outcome of certain human polymicrobial infections. |
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Authors:
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Sandra Schwarz; Rachel D Hood; Joseph D Mougous |
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Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't Date: 2010-10-18 |
Journal Detail:
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Title: Trends in microbiology Volume: 18 ISSN: 1878-4380 ISO Abbreviation: Trends Microbiol. Publication Date: 2010 Dec |
Date Detail:
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Created Date: 2010-11-24 Completed Date: 2011-01-14 Revised Date: 2011-12-21 |
Medline Journal Info:
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Nlm Unique ID: 9310916 Medline TA: Trends Microbiol Country: England |
Other Details:
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Languages: eng Pagination: 531-7 Citation Subset: IM |
Copyright Information:
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Copyright © 2010 Elsevier Ltd. All rights reserved. |
Affiliation:
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Department of Microbiology, University of Washington, Seattle, WA 98195, USA. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Bacteria
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metabolism*,
pathogenicity Bacterial Infections / microbiology Bacterial Proteins / metabolism Bacterial Secretion Systems* Gene Expression Regulation, Bacterial Host-Pathogen Interactions Humans |
| Grant Support | |
ID/Acronym/Agency:
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AI057141/AI/NIAID NIH HHS; AI080609/AI/NIAID NIH HHS; R01 AI080609-01A1/AI/NIAID NIH HHS; R01 AI080609-02/AI/NIAID NIH HHS; R01 AI080609-03/AI/NIAID NIH HHS; U54 AI057141-066257/AI/NIAID NIH HHS; U54 AI057141-076257/AI/NIAID NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Bacterial Proteins |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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