| What triggers cell-mediated mineralization? | |
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MedLine Citation:
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PMID: 17127268 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Mineralization is an essential requirement for normal skeletal development, but under certain pathological conditions organs like articular cartilage and cardiovascular tissue are prone to unwanted mineralization. Recent findings suggest that the mechanisms regulating skeletal mineralization may be similar to those regulating pathological mineralization. In general, three forms of cell-mediated mineralization are recognized in an organism: intramembranous ossification, endochondral ossification and pathological mineralization. This review summarizes recent work that tried to elucidate how cell-mediated mineralization is initiated and regulated. To explain mineralization, several theories have been proposed. One theory proposes that mineralization is initiated within matrix vesicles (MVs). A second, not mutually exclusive, theory proposes that phosphate induces apoptosis, and that apoptotic bodies nucleate crystals composed of calcium and phosphate. A third theory suggests that mineralization is mediated by certain non-collagenous proteins, which associate with the extracellular matrix. Regardless of the way mineralization is initiated, the organism also actively inhibits mineralization by specific proteins and removal of an inhibitor may also induce mineralization. Although many studies greatly contributed to a better understanding of the mechanisms regulating cell-mediated mineralization, many questions remain about the mechanisms that trigger cell-mediated mineralization and how this process is regulated. Further investigation is necessary to develop in the future novel therapeutic strategies to prevent pathological mineralization. |
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Authors:
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Leonie F A Huitema; Arie B Vaandrager |
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Publication Detail:
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Type: Journal Article; Review Date: 2007-01-01 |
Journal Detail:
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Title: Frontiers in bioscience : a journal and virtual library Volume: 12 ISSN: 1093-4715 ISO Abbreviation: Front. Biosci. Publication Date: 2007 |
Date Detail:
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Created Date: 2006-11-27 Completed Date: 2007-08-23 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9709506 Medline TA: Front Biosci Country: United States |
Other Details:
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Languages: eng Pagination: 2631-45 Citation Subset: IM |
Affiliation:
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Department of Biochemistry and Cell Biology, Faculty of Veterinary Medicine, and Graduate School of Animal Health, Utrecht University, Utrecht, The Netherlands. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Apoptosis Calcification, Physiologic* Calcinosis / etiology Cytoplasmic Vesicles / metabolism Extracellular Matrix / metabolism Extracellular Matrix Proteins / physiology Humans Mice alpha-Fetoproteins / physiology |
| Chemical | |
Reg. No./Substance:
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0/Extracellular Matrix Proteins; 0/alpha-Fetoproteins |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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