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What is special about the adolescent (JME) brain?
MedLine Citation:
PMID:  23756479     Owner:  NLM     Status:  In-Data-Review    
Abstract/OtherAbstract:
Juvenile myoclonic epilepsy (JME) involves cortico-thalamo-cortical networks. Thalamic, frontal gray matter, connectivity, and neurotransmitter disturbances have been demonstrated by structural/functional imaging studies. Few patients with JME show mutations in genes coding ion channels or GABAA (gamma-aminobutyric acid) receptor subunits. Recent research points to EFHC1 gene mutations leading to microdysgenesis and possible aberrant circuitry. Imaging studies have shown massive structural/functional changes of normally developing adolescent brain structures maturing at strikingly different rates and times. Gray matter (GM) volume diminishes in cortical areas (frontal and parietal) and deep structures (anterior thalamus, putamen, and caudate). Diffusion tensor imaging (DTI) findings support continued microstructural change in WM (white matter) during late adolescence with robust developmental changes in thalamocortical connectivity. The GABAA receptor distribution and specific receptor subunits' expression patterns change with age from neonate to adolescent/adult, contributing to age-related changes in brain excitability. Hormonal influence on brain structure development during adolescence is presented. Possible implications of brain changes during adolescence on the course of JME are discussed. This article is part of a supplemental special issue entitled Juvenile Myoclonic Epilepsy: What is it Really?
Authors:
Dana Craiu
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Epilepsy & behavior : E&B     Volume:  28 Suppl 1     ISSN:  1525-5069     ISO Abbreviation:  Epilepsy Behav     Publication Date:  2013 Jul 
Date Detail:
Created Date:  2013-06-12     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  100892858     Medline TA:  Epilepsy Behav     Country:  United States    
Other Details:
Languages:  eng     Pagination:  S45-51     Citation Subset:  IM    
Copyright Information:
Copyright © 2012 Elsevier Inc. All rights reserved.
Affiliation:
Pediatric Neurology Clinic, Alexandru Obregia Clinical Hospital, "Carol Davila" University of Medicine, Bucharest, Romania. Electronic address: dcraiu@yahoo.com.
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