| What should we be fine tuning in acute coronary syndromes--dosing of antiplatelet therapy or data presentation? | |
| | |
MedLine Citation:
|
PMID: 21177417 Owner: NLM Status: In-Process |
Abstract/OtherAbstract:
|
The CURRENT OASIS 7 (The Clopidogrel and Aspirin Optimal Dose Usage to Reduce Recurrent Events-Seventh Organization to Assess Strategies in Ischemic Syndromes) trial recently published in the New England Journal of Medicine and a subgroup of this trial published in The Lancet evaluated alternative dosing strategies for clopidogrel and aspirin in the treatment of acute coronary syndromes. Critiques of these clinical trial data have been previously published and debated, but this study brings to light another area of scientific discussion. Using this trial as an example, this commentary emphasizes several key aspects of the clinical trial data presentation and publication process that need to improve and reminds clinicians of the many limitations to subgroup analyses. |
| | |
Authors:
|
Carrie W Nemerovski; Michael P Dorsch; Douglas L Jennings |
Related Documents
:
|
19793617 - Apical-sparing tako-tsubo: a case report. 9830697 - Intermediate syndrome with delayed distal polyneuropathy from ethyl parathion poisoning. 18973397 - Bivalirudin: in patients with acute coronary syndromes : planned for urgent or early in... 20548817 - Antiplatelet therapy and percutaneous coronary intervention in patients with acute coro... 8822697 - The ictal bradycardia syndrome. 7492167 - Growth hormone deficiency and empty sella in didmoad syndrome: an endocrine study. |
Publication Detail:
|
Type: Journal Article Date: 2010-12-21 |
Journal Detail:
|
Title: The Annals of pharmacotherapy Volume: 45 ISSN: 1542-6270 ISO Abbreviation: Ann Pharmacother Publication Date: 2011 Jan |
Date Detail:
|
Created Date: 2011-01-13 Completed Date: - Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 9203131 Medline TA: Ann Pharmacother Country: United States |
Other Details:
|
Languages: eng Pagination: 120-2 Citation Subset: IM |
Affiliation:
|
Wayne State University, Detroit, MI, USA. cnemerovski@wayne.edu |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
|
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Identification and Mechanism of Action of the Acylguanidine MRT-83, a Novel Potent Smoothened Antago...
Next Document: Defining reality: the potential role of pharmacists in assessing the impact of progesterone receptor...