Document Detail


What shapes pulse amplitude of intracranial pressure?
MedLine Citation:
PMID:  19852586     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The pulsatile component of intracranial pressure (ICP) has been shown to be a predictor of outcome in normal pressure hydrocephalus (NPH) and traumatic brain injury (TBI). Experimental studies have demonstrated that the pulse amplitude of ICP (AMP(ICP)) is dependent on the mean ICP (mICP), and on the pulse amplitude of the cerebral arterial blood volume (AMP(CaBV)), according to the exponential craniospinal compliance curve. In this study, we compared the influence of mICP and AMP(CaBV) on AMP(ICP) in patients with NPH (infusion study) and TBI (spontaneous recording). We retrospectively analyzed 25 NPH and 43 TBI patients with continuous monitoring of ICP and cerebral blood flow velocity (CBFV), as assessed with transcranial doppler. AMP(CaBV) was extracted from the CBFV waveform. The influence of mICP and AMP(CaBV) on AMP(ICP) were determined using partial coefficients a, b, and c of the multiple regression model: AMP(ICP) = a * mICP + b * AMP(CaBV) + c. AMP(ICP) was more dependent on mICP in NPH patients than in TBI patients (partial coefficient a = 0.93 versus -0.03; p < 0.001). On the contrary, AMP(ICP) was more dependent on AMP(CaBV) in patients with TBI than in those with NPH (b = 0.86 versus 0.10; p < 0.001). This study shows that AMP(ICP) depends mostly on changes in mean ICP during cerebrospinal fluid (CSF) infusion studies in patients with NPH, and on changes in cerebral arterial blood volume (AMP(CaBV)) in TBI patients. Further clinical studies will reveal whether AMP(ICP) is a better indicator of clinical severity and outcome than mICP in TBI and NPH patients.
Authors:
Emmanuel Carrera; Dong-Joo Kim; Gianluca Castellani; Christian Zweifel; Zofia Czosnyka; Magdalena Kasparowicz; Peter Smielewski; John D Pickard; Marek Czosnyka
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Journal of neurotrauma     Volume:  27     ISSN:  1557-9042     ISO Abbreviation:  J. Neurotrauma     Publication Date:  2010 Feb 
Date Detail:
Created Date:  2010-02-22     Completed Date:  2010-05-11     Revised Date:  2014-02-19    
Medline Journal Info:
Nlm Unique ID:  8811626     Medline TA:  J Neurotrauma     Country:  United States    
Other Details:
Languages:  eng     Pagination:  317-24     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Adult
Brain / blood supply,  physiopathology*
Brain Injuries / physiopathology*
Cerebrovascular Circulation / physiology
Female
Humans
Hydrocephalus, Normal Pressure / physiopathology*
Intracranial Pressure / physiology*
Male
Middle Aged
Models, Theoretical*
Pulse*
Retrospective Studies
Ultrasonography, Doppler, Transcranial
Grant Support
ID/Acronym/Agency:
G9439390//Medical Research Council

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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