Document Detail

What role do adrenoreceptor polymorphisms play in modifying cardiovascular responses in obstructive sleep apnoea?
MedLine Citation:
PMID:  16287427     Owner:  NLM     Status:  MEDLINE    
OSA (obstructive sleep apnoea) is a common condition that is strongly associated with cardiovascular disease. It is remains unclear what role OSA plays in determining cardiovascular risk. The immediate physiological changes that occur during upper airway obstruction are potential contributors to cardiovascular risk in OSA. These changes include increased sympathetic activity, which is responsive to treatment of OSA with CPAP (continuous positive airway pressure). In this issue of Clinical Science, the possible role of a common polymorphism in the beta1-adrenoreceptor [R389G (Arg389Gly)] has been investigated by Börgel and co-workers. Measurements of heart rate and blood pressure in untreated OSA patients were not related to the R389G polymorphism. There were changes in heart rate and diastolic blood pressure with CPAP treatment that were related to this polymorphism. Reduction in heart rate with CPAP treatment was associated with the R389R genotype. By contrast, a reduction in diastolic blood pressure was associated with the Gly389 carriers. These findings are intriguing, but difficult to fully explain. Further study is needed to determine if there is an important role of the R389G polymorphism in modifying cardiovascular responses among OSA patients.
Nigel McArdle
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Publication Detail:
Type:  Comment; Journal Article    
Journal Detail:
Title:  Clinical science (London, England : 1979)     Volume:  110     ISSN:  0143-5221     ISO Abbreviation:  Clin. Sci.     Publication Date:  2006 Jan 
Date Detail:
Created Date:  2005-12-12     Completed Date:  2006-03-07     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  7905731     Medline TA:  Clin Sci (Lond)     Country:  England    
Other Details:
Languages:  eng     Pagination:  89-91     Citation Subset:  IM    
University Department of Medicine, Royal Perth Hospital, Wellington Street, Perth, WA 6000, Australia.
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MeSH Terms
Cardiovascular Diseases / etiology,  genetics*
Genetic Predisposition to Disease
Polymorphism, Genetic*
Receptors, Adrenergic, beta-1 / genetics*
Sleep Apnea, Obstructive / complications,  genetics*
Reg. No./Substance:
0/Receptors, Adrenergic, beta-1
Comment On:
Clin Sci (Lond). 2006 Jan;110(1):117-23   [PMID:  16122377 ]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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