| What is the role of biomarker measurement after cardiac surgery? | |
| | |
MedLine Citation:
|
PMID: 21441887 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
|
Measurements of cardiac troponin (cTn) and natriuretic peptides can predict outcomes after cardiac surgery and may thus assist in decision making about diagnostic and therapeutic steps in this setting. Not every cardiac surgical procedure is associated with the same degree of cTn or natriuretic peptide elevation; the factors known to affect concentrations of these markers include the severity of preoperative coronary artery disease as well as presenting syndrome, while forms of cardioprotection and anesthesia may affect postoperative concentrations of biomarkers. Release of cTn appears to represent irreversibly damaged myocardium; however, clinicians are cautioned when measuring cTn in post-cardiac surgery venues not to assume an elevated concentration is equivalent to regional acute myocardial infarction; indeed, more often than not, excessive values of cTnT or cTnI more typically represent diffuse myocardial injury. Natriuretic peptide release may occur through both states of irreversible dysfunction as well as more reversible states, such as postoperative shock. Indeed, both cTn and natriuretic peptides are unequivocally prognostic for delayed recovery, intensive care unit utilization, as well as short- and longer-term mortalities following cardiac surgery. |
| | |
Authors:
|
J L Januzzi |
Related Documents
:
|
18182757 - Use of intraaortic balloon counter pulsation in a patient with tortuous aorta. 19789687 - Usefulness of remote magnetic navigation for ablation of ventricular arrhythmias origin... 15383777 - Comparison of presystolic purkinje and late diastolic potentials for selection of ablat... 1338007 - Follow-up of a modified catheter ablation of the atrioventricular junction in patients ... 1806377 - Antiaggregating therapy in acute myocardial infarction. 21868467 - Obesity and right ventricular structure and function: the mesa-right ventricle study. |
Publication Detail:
|
Type: Journal Article |
Journal Detail:
|
Title: Minerva anestesiologica Volume: 77 ISSN: 1827-1596 ISO Abbreviation: Minerva Anestesiol Publication Date: 2011 Mar |
Date Detail:
|
Created Date: 2011-03-28 Completed Date: - Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 0375272 Medline TA: Minerva Anestesiol Country: Italy |
Other Details:
|
Languages: eng Pagination: 334-41 Citation Subset: IM |
Affiliation:
|
Cardiology Division and Department of Medicine, Massachusetts General Hospital, Boston, MA, USA - JJanuzzi@partners.org. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
|
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Non-invasive ventilation outside of the Intensive Care Unit: an Italian survey.
Next Document: Non invasive ventilation in immunocompromised patients.