| What is the relationship between myocardial perfusion imaging and coronary artery disease risk factors and markers of inflammation? | |
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MedLine Citation:
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PMID: 18319218 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The treatment of coronary artery disease (CAD) is clinically measured by monitoring changes in venous lipids and inflammatory markers. There is currently no established quantified relationship between coronary flow reserve and markers of inflammatory CAD. A total of 120 men and women underwent quantified measurement of coronary blood flow using SPECT imaging at baseline and 1 year later. They had fasting venous blood work obtained at baseline and 1 year later. These markers of lipids and inflammation included, total cholesterol, low-density lipoprotein cholesterol, very low-density lipoprotein cholesterol, high-density lipoprotein cholesterol, triglycerides, lipoprotein-a, homocysteine, fibrinogen, C-reactive protein, and interleukin-6. Regression analysis reveals no general statistical relationship between these markers and coronary blood flow as measured by myocardial perfusion imaging. However, when changes in indices are considered and changes in risk factors are compared with changes in ischemia, blood factor based estimates yield an adjusted R2 = 0.31, R = 0.57, P < .0001. Initial levels of coronary ischemia cannot be diagnostically inferred from baseline values in lipid and inflammatory markers of coronary artery disease. When change in coronary blood flow is quantified using SPECT imaging, 6 independent underlying blood factors provided statistically useful information in identifying changes in coronary blood flow. Although the relationship of changes is statistically significant ( P < .0001), quantification of coronary blood flow by SPECT imaging provides physiologic status information, which cannot be inferred from fasting markers of lipids and inflammation status. |
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Authors:
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Richard M Fleming; Gordon M Harrington |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Angiology Volume: 59 ISSN: 0003-3197 ISO Abbreviation: Angiology Publication Date: 2008 Feb-Mar |
Date Detail:
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Created Date: 2008-03-05 Completed Date: 2008-04-04 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0203706 Medline TA: Angiology Country: United States |
Other Details:
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Languages: eng Pagination: 16-25 Citation Subset: IM |
Affiliation:
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Critical Care and Cardiology, Department of Internal Medicine, Sierra Nevada Veterans Affairs Health Care System, Reno, Nevada 89502-2597, USA. rmfmd7@ hotmail.com |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adult Biological Markers / blood Coronary Artery Disease / blood, complications, etiology, physiopathology, radionuclide imaging* Coronary Circulation* Female Follow-Up Studies Fractional Flow Reserve, Myocardial Humans Inflammation / blood*, complications Inflammation Mediators / blood* Lipids / blood* Male Middle Aged Myocardial Ischemia / blood, etiology*, physiopathology, radionuclide imaging Risk Assessment Risk Factors Time Factors Tomography, Emission-Computed, Single-Photon* |
| Chemical | |
Reg. No./Substance:
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0/Biological Markers; 0/Inflammation Mediators; 0/Lipids |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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