Document Detail

What is the real incidence of vestibular schwannoma?
MedLine Citation:
PMID:  14967754     Owner:  NLM     Status:  MEDLINE    
OBJECTIVES: To present the incidence of vestibular schwannoma (VS) in Denmark, compare the incidence with that of previous periods, and discuss the real incidence of VS. DESIGN, SETTING, AND PATIENTS: Prospective registration of all diagnosed VS in Denmark, with a population of 5.1 to 5.2 million, during the 6 years from January 1996 through December 2001. Incidence in this period was compared with that of 3 previous periods (July 1976 through June 1983 [first period], July 1983 through June 1990 [second period], and July 1990 through December 1995 [third period]). RESULTS: In the 1996-2001 period, 542 cases of VS were diagnosed, representing a mean incidence of 17.4 VS/1 million inhabitants per year. Of these, 227 tumors underwent operation, 14 underwent irradiation, and 301 were allocated to observation (wait-and-scan policy). One hundred sixty-six tumors were intrameatal. Size of extrameatal tumors was small in 104; medium in 194; large in 68; and giant (>40 mm) in 10. Compared with incidences of 7.8 VS/1 million inhabitants per year in the first, 9.4 VS/1 million inhabitants in the second, and 12.4 VS/1 million inhabitants in the third periods, the incidence for the 1996-2001 period represents an increase to 17.4 VS/1 million inhabitants per year. The mean incidence for the entire 25.5-year period was 11.5 VS/1 million inhabitants per year. CONCLUSIONS: An estimate of a realistic mean incidence of VS depends on the observation period. Our 25.5-year registration of an entire population showed a mean incidence of 11.5 VS/1 million inhabitants per year. However, the latest period registered represents an incidence of 17.4 VS/1 million inhabitants per year, which, combined with a probable further increase of diagnosed tumors in forthcoming years, suggests a realistic incidence of approximately 13 VS/1 million inhabitants per year.
Mirko Tos; Sven-Eric Stangerup; Per Cayé-Thomasen; Tina Tos; Jens Thomsen
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Archives of otolaryngology--head & neck surgery     Volume:  130     ISSN:  0886-4470     ISO Abbreviation:  Arch. Otolaryngol. Head Neck Surg.     Publication Date:  2004 Feb 
Date Detail:
Created Date:  2004-02-17     Completed Date:  2004-03-04     Revised Date:  2006-03-28    
Medline Journal Info:
Nlm Unique ID:  8603209     Medline TA:  Arch Otolaryngol Head Neck Surg     Country:  United States    
Other Details:
Languages:  eng     Pagination:  216-20     Citation Subset:  AIM; IM    
Department of Otorhinolaryngology-Head and Neck Surgery, Gentofte Hospital, University of Copenhagen, Copenhagen, Denmark.
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MeSH Terms
Neuroma, Acoustic / epidemiology*
Population Surveillance
Prospective Studies
Time Factors

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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