| What is potent acid inhibition, and how can it be achieved? | |
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MedLine Citation:
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PMID: 16335854 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The clinical response to antisecretory treatment correlates directly with the degree of inhibition of acid secretion achieved. Acid inhibition able to maintain the intragastric pH at a value greater than 4 for at least 16 h/day seems to heal even the most refractory acid-related diseases. It has also been shown that the degree of inhibition of acid secretion in response to antisecretory treatment depends on the genetic characteristics of the patient and on the presence of Helicobacter pylori infection. A possible definition of potent (or profound) acid inhibition is, therefore, the achievement of the aforementioned level of control of acid secretion regardless of patient characteristics or of the presence of H. pylori infection. Antisecretory drugs differ in their ability to reach potent acid inhibition. As far as the comparative efficacy of different drugs for inhibiting acid secretion is concerned, proton pump inhibitors are more efficient in inhibiting gastric acid secretion than histamine (H2) receptor antagonists. Among the different proton pump inhibitors, esomeprazole 40 mg/day exhibits greater antisecretory potency than the others at standard doses. Rabeprazole 20 mg/day and lansoprazole 30 mg/day exhibit a more rapid onset of action than omeprazole 20 mg/day or pantoprazole 40 mg/day. |
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Authors:
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Xavier Calvet; Fernando Gomollón |
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Publication Detail:
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Type: Journal Article; Review |
Journal Detail:
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Title: Drugs Volume: 65 Suppl 1 ISSN: 0012-6667 ISO Abbreviation: Drugs Publication Date: 2005 |
Date Detail:
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Created Date: 2005-12-12 Completed Date: 2005-12-23 Revised Date: 2013-04-16 |
Medline Journal Info:
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Nlm Unique ID: 7600076 Medline TA: Drugs Country: New Zealand |
Other Details:
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Languages: eng Pagination: 13-23 Citation Subset: IM |
Affiliation:
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Digestive Diseases Unit, Sabadell Hospital, Parc Taulí University Institute, Autonomous University of Barcelona, Spain. xcalvet@cspt.es |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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2-Pyridinylmethylsulfinylbenzimidazoles Anti-Ulcer Agents / administration & dosage* Benzimidazoles / administration & dosage Clinical Trials as Topic Esomeprazole Sodium Gastric Acid / secretion* Humans Omeprazole / administration & dosage, analogs & derivatives Peptic Ulcer / drug therapy* Proton Pumps / antagonists & inhibitors* Sulfoxides / administration & dosage |
| Chemical | |
Reg. No./Substance:
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0/2-Pyridinylmethylsulfinylbenzimidazoles; 0/Anti-Ulcer Agents; 0/Benzimidazoles; 0/Proton Pumps; 0/Sulfoxides; 102625-70-7/pantoprazole; 103577-45-3/lansoprazole; 32828355LL/rabeprazole; 73590-58-6/Omeprazole; L2C9GWQ43H/Esomeprazole Sodium |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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