| What is the place of thrombolysis in acute stroke? A review of the literature and a current perspective. | |
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MedLine Citation:
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PMID: 18624029 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The global burden of stroke, the undisputed success of intravenous thrombolysis in the management of myocardial infarction and subsequent evidence from animal models of cerebral infarction have all fuelled intense interest in the potential role for thrombolytic agents in the acute management of stroke in clinical practice. Before any clinical treatment is introduced universally its safety and efficacy must be demonstrated in the routine clinical environment and not just within the ideal conditions of controlled clinical trials. Similarly, the cost effectiveness of a new treatment modality is an essential consideration before its use is promulgated. This paper reviews the current scientific evidence for thrombolysis in stroke with reference to issues of safety, efficacy and cost effectiveness. |
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Authors:
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Peter O Jenkins; Martin R Turner; Paul F Jenkins |
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Publication Detail:
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Type: Journal Article; Review |
Journal Detail:
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Title: Clinical medicine (London, England) Volume: 8 ISSN: 1470-2118 ISO Abbreviation: Clin Med Publication Date: 2008 Jun |
Date Detail:
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Created Date: 2008-07-15 Completed Date: 2008-10-28 Revised Date: 2009-01-28 |
Medline Journal Info:
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Nlm Unique ID: 101092853 Medline TA: Clin Med Country: England |
Other Details:
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Languages: eng Pagination: 253-8 Citation Subset: IM |
Affiliation:
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Guys and St Thomas' Hospital, London. peterowenjenkins@yahoo.com |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Acute Disease Animals Clinical Competence Cost-Benefit Analysis Fibrinolytic Agents / therapeutic use Humans Incidence Risk Factors Stroke / epidemiology, prevention & control* Thrombolytic Therapy / economics, utilization* Treatment Outcome |
| Chemical | |
Reg. No./Substance:
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0/Fibrinolytic Agents |
| Comments/Corrections | |
Comment In:
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Clin Med. 2008 Oct;8(5):556; author reply 556
[PMID:
18975495
]
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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