Document Detail


What is the optimum adjunctive reperfusion strategy for primary percutaneous coronary intervention?
MedLine Citation:
PMID:  23953387     Owner:  NLM     Status:  In-Process    
Abstract/OtherAbstract:
Acute ST-segment elevation myocardial infarction (STEMI) is a dynamic, thrombus-driven event. As understanding of its pathophysiology has improved, the central role of platelets in initiation and orchestration of this process has become clear. Key components of STEMI include formation of occlusive thrombus, mediation and ultimately amplification of the local vascular inflammatory response resulting in increased vasoreactivity, oedema formation, and microvascular obstruction. Activation, degranulation, and aggregation of platelets are the platforms from which these components develop. Therefore, prompt, potent, and predictable antithrombotic therapy is needed to optimise clinical outcomes after primary percutaneous coronary intervention. We review present pharmacological and mechanical adjunctive therapies for reperfusion and ask what is the optimum combination when primary percutaneous coronary intervention is used as the mode of revascularisation in patients with STEMI.
Authors:
Nicholas Curzen; Paul A Gurbel; Aung Myat; Deepak L Bhatt; Simon R Redwood
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Lancet     Volume:  382     ISSN:  1474-547X     ISO Abbreviation:  Lancet     Publication Date:  2013 Aug 
Date Detail:
Created Date:  2013-08-19     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  2985213R     Medline TA:  Lancet     Country:  England    
Other Details:
Languages:  eng     Pagination:  633-43     Citation Subset:  AIM; IM    
Copyright Information:
Copyright © 2013 Elsevier Ltd. All rights reserved.
Affiliation:
Wessex Cardiothoracic Unit, University Hospital Southampton NHS Foundation Trust, Southampton, UK. nick.curzen@uhs.nhs.uk
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MeSH Terms
Descriptor/Qualifier:
Grant Support
ID/Acronym/Agency:
FS/11/70/28917//British Heart Foundation; //Department of Health

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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