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What is the optimal management option for occupational asthma?
MedLine Citation:
PMID:  22654081     Owner:  NLM     Status:  Publisher    
The optimal management of occupational asthma remains uncertain in clinical practice. The aim of this review was to analyse the published information pertaining to the management of occupational asthma in order to produce evidence-based statements and recommendations. A systematic literature search was conducted up to March 2010 to identify original studies addressing the following different treatment options: 1) persistence of exposure; 2) pharmacological treatment; 3) complete avoidance of exposure; 4) reduction of exposure; and 5) the use of personal protective equipment. After full text evaluation of 83 potentially relevant articles, 52 studies were retained for analysis. The conclusions from this systematic review are limited by the methodological weaknesses of most published studies. Critical analysis of available evidence indicates that: 1) persistent exposure to the causal agent is more likely to result in asthma worsening than complete avoidance; 2) there is insufficient evidence to determine whether pharmacological treatment can alter the course of asthma in subjects who remain exposed; 3) avoidance of exposure leads to recovery of asthma in less than one-third of affected workers; 4) reduction of exposure seems to be less beneficial than complete avoidance of exposure; and 5) personal respiratory equipment does not provide complete protection.
Olivier Vandenplas; Holger Dressel; Dennis Nowak; Jacques Jamart;
Publication Detail:
Journal Detail:
Title:  European respiratory review : an official journal of the European Respiratory Society     Volume:  21     ISSN:  1600-0617     ISO Abbreviation:  -     Publication Date:  2012 Jun 
Date Detail:
Created Date:  2012-6-1     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9111391     Medline TA:  Eur Respir Rev     Country:  -    
Other Details:
Languages:  ENG     Pagination:  97-104     Citation Subset:  -    
Dept of Chest Medicine, and + Scientific Support Unit, Mont-Godinne Hospital, Université Catholique De Louvain, Yvoir, Belgium. # Städt. Klinikum München GmbG, Klinikum Neuperlach Zentrum für Akutgeriatrie und Frührehabilitation. and ¶ Institute und Poliklinik für Arbeits- und Umweltmedizin der Ludwig-Maximilians-Universität, Klinikum der Universität München, Munich, Germany. § For a full list of the members of the Task Force, see the Acknowledgements.
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