| What is the optimal dose of epinephrine during cardiopulmonary resuscitation in a rat model? | |
| | |
MedLine Citation:
|
PMID: 20223384 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
OBJECTIVE: Because different species may require different doses of drug to produce the same physiologic response, we were provoked to evaluate the dose-response of epinephrine during cardiopulmonary resuscitation (CPR) and identify what is the optimal dose of epinephrine in a rat cardiac arrest model. METHODS: Rat cardiac arrest was induced via asphyxia, and then the effects of different doses of epinephrine (0.04, 0.2, and 0.4 mg/kg IV, respectively) and saline on the outcome of CPR were compared (n = 10/each group). The primary outcome measure was restoration of spontaneous circulation (ROSC), and the secondary was the change of spontaneous respiration and hemodynamics after ROSC. RESULTS: Rates of ROSC were 9 of 10, 8 of 10, 7 of 10, and 1 of 10 in the low-dose, medium-dose, and high-dose epinephrine groups and saline group, respectively. The rates of withdrawal from the ventilator within 60 minutes in the low-dose (7 of 9) and medium-dose epinephrine groups (7 of 8) were higher than in the high-dose epinephrine group (1 of 7, P < .05). Mean arterial pressures were comparable, but the heart rate in the high-dose epinephrine group was the lowest among epinephrine groups after ROSC. These differences in part of time points reached statistical significance (P < .05). CONCLUSION: Different doses of epinephrine produced the similar rate of ROSC, but high-dose epinephrine inhibited the recovery of spontaneous ventilation and caused relative bradycardia after CPR in an asphyxial rat model. Therefore, low and medium doses of epinephrine were more optimal for CPR in a rat asphyxial cardiac arrest model. |
| | |
Authors:
|
Meng-Hua Chen; Jun-Yu Lu; Lu Xie; Jun-Hui Zheng; Feng-Qing Song |
Related Documents
:
|
11236904 - Effects of dobutamine on hepato-splanchnic hemodynamics in an experimental model of hyp... 1327634 - Effect of l-alanine infusion on 31p nuclear magnetic resonance spectra of normal human ... 10234594 - Sustained hemodynamic effects of the selective dopamine-1 agonist, fenoldopam, during 4... 1234014 - Intravenous infusion of salbutamol in the treatment of asthma. 1694714 - The inhibitory effect of terfenadine and flurbiprofen on early and late-phase bronchoco... 18266604 - Safety, pharmacokinetics, and antiviral activity of hgs004, a novel fully human igg4 mo... |
Publication Detail:
|
Type: Comparative Study; Journal Article; Research Support, Non-U.S. Gov't Date: 2010-01-28 |
Journal Detail:
|
Title: The American journal of emergency medicine Volume: 28 ISSN: 1532-8171 ISO Abbreviation: Am J Emerg Med Publication Date: 2010 Mar |
Date Detail:
|
Created Date: 2010-03-12 Completed Date: 2010-05-06 Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 8309942 Medline TA: Am J Emerg Med Country: United States |
Other Details:
|
Languages: eng Pagination: 284-90 Citation Subset: IM |
Copyright Information:
|
2010 Elsevier Inc. All rights reserved. |
Affiliation:
|
Institute of Cardiovascular Diseases, the First Affiliated Hospital of Guangxi Medical University, Nanning, PR China. cmhnn@sina.com |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Animals Cardiopulmonary Resuscitation / methods* Epinephrine / administration & dosage*, pharmacology Male Models, Animal Rats Rats, Sprague-Dawley Statistics, Nonparametric |
| Chemical | |
Reg. No./Substance:
|
51-43-4/Epinephrine |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Practice variation in the management for nontraumatic pediatric patients in the ED.
Next Document: Does diagnosis change as a result of repeat renal colic computed tomography scan in patients with a ...