| What next for preimplantation genetic screening? A clinician's perspective. | |
MedLine Citation:
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PMID: 18579511 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Preimplantation genetic screening (PGS) is a technique that has been introduced into clinical practice to screen and eliminate aneuploid embryos from transfer with the intention to improve implantation rates and decrease pregnancy wastage. Although practiced widely throughout the world, PGS unfortunately has been adopted without being subjected to rigorous scientific validation. Data from recent randomized trials have shed doubt on the efficacy of the procedure when used in women with advanced age, one of the target populations for PGS. Other purported indications for the application of this complicated technique such as recurrent implantation failure and recurrent spontaneous abortion have not been subjected to randomized controlled trials. For the best interest of patients, we feel it is timely for a debate regarding the efficacy and safety of PGS. |
Authors:
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Kayhan Yakin; Bulent Urman |
Publication Detail:
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Type: Journal Article Date: 2008-06-24 |
Journal Detail:
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Title: Human reproduction (Oxford, England) Volume: 23 ISSN: 1460-2350 ISO Abbreviation: Hum. Reprod. Publication Date: 2008 Aug |
Date Detail:
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Created Date: 2008-07-18 Completed Date: 2008-09-29 Revised Date: 2009-11-19 |
Medline Journal Info:
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Nlm Unique ID: 8701199 Medline TA: Hum Reprod Country: England |
Other Details:
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Languages: eng Pagination: 1686-90 Citation Subset: IM |
Affiliation:
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VKF American Hospital of Istanbul, Assisted Reproduction Unit, Guzelbahce Sokak No. 20, Nisantasi, Istanbul 34365, Turkey. kyakin@yahoo.com |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Abortion, Habitual Adult Aneuploidy Embryo Implantation Female Genetic Testing / methods Humans Maternal Age Preimplantation Diagnosis / standards* Randomized Controlled Trials as Topic Recurrence Treatment Failure |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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