Document Detail

What next for preimplantation genetic screening? A clinician's perspective.
MedLine Citation:
PMID:  18579511     Owner:  NLM     Status:  MEDLINE    
Preimplantation genetic screening (PGS) is a technique that has been introduced into clinical practice to screen and eliminate aneuploid embryos from transfer with the intention to improve implantation rates and decrease pregnancy wastage. Although practiced widely throughout the world, PGS unfortunately has been adopted without being subjected to rigorous scientific validation. Data from recent randomized trials have shed doubt on the efficacy of the procedure when used in women with advanced age, one of the target populations for PGS. Other purported indications for the application of this complicated technique such as recurrent implantation failure and recurrent spontaneous abortion have not been subjected to randomized controlled trials. For the best interest of patients, we feel it is timely for a debate regarding the efficacy and safety of PGS.
Kayhan Yakin; Bulent Urman
Publication Detail:
Type:  Journal Article     Date:  2008-06-24
Journal Detail:
Title:  Human reproduction (Oxford, England)     Volume:  23     ISSN:  1460-2350     ISO Abbreviation:  Hum. Reprod.     Publication Date:  2008 Aug 
Date Detail:
Created Date:  2008-07-18     Completed Date:  2008-09-29     Revised Date:  2009-11-19    
Medline Journal Info:
Nlm Unique ID:  8701199     Medline TA:  Hum Reprod     Country:  England    
Other Details:
Languages:  eng     Pagination:  1686-90     Citation Subset:  IM    
VKF American Hospital of Istanbul, Assisted Reproduction Unit, Guzelbahce Sokak No. 20, Nisantasi, Istanbul 34365, Turkey.
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MeSH Terms
Abortion, Habitual
Embryo Implantation
Genetic Testing / methods
Maternal Age
Preimplantation Diagnosis / standards*
Randomized Controlled Trials as Topic
Treatment Failure

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