| What limits the evolutionary emergence of pathogens? | |
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MedLine Citation:
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PMID: 23209168 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
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The ability of a pathogen to cause an epidemic when introduced in a new host population often relies on its ability to adapt to this new environment. Here, we give a brief overview of recent theoretical and empirical studies of such evolutionary emergence of pathogens. We discuss the effects of several ecological and genetic factors that may affect the likelihood of emergence: migration, life history of the infectious agent, host heterogeneity, and the rate and effects of mutations. We contrast different modelling approaches and indicate how details in the way we model each step of a life cycle can have important consequences on the predicted probability of evolutionary emergence. These different theoretical perspectives yield important insights into optimal surveillance and intervention strategies, which should aim for a reduction in the emergence (and re-emergence) of infectious diseases. |
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Authors:
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S Gandon; M E Hochberg; R D Holt; T Day |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Philosophical transactions of the Royal Society of London. Series B, Biological sciences Volume: 368 ISSN: 1471-2970 ISO Abbreviation: Philos. Trans. R. Soc. Lond., B, Biol. Sci. Publication Date: 2013 Jan |
Date Detail:
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Created Date: 2012-12-04 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 7503623 Medline TA: Philos Trans R Soc Lond B Biol Sci Country: England |
Other Details:
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Languages: eng Pagination: 20120086 Citation Subset: IM |
Affiliation:
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CEFE, CNRS, , 1919 route de Mende, Montpellier, 34293, France. |
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