Document Detail


What is left behind--quality control in germ cell migration.
MedLine Citation:
PMID:  17456805     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Cell differentiation, cell proliferation, cell death, and cell migration are tightly controlled during animal development and adult homeostasis. Failure to regulate these processes can result in tumor formation and metastasis. Aberrant cells are therefore often cleared by induction of cell death. Recent work has elucidated the mechanism of elimination of mouse primordial germ cells that fail to migrate properly and highlights the similarity of this mechanism to those governing the same phenomenon in Drosophila. In addition, these studies underscore the different functions a single signaling pathway can have in controlling cell survival, cell proliferation, and cell migration during different phases of development.
Authors:
Bijan Boldajipour; Erez Raz
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Publication Detail:
Type:  Journal Article; Review     Date:  2007-04-24
Journal Detail:
Title:  Science's STKE : signal transduction knowledge environment     Volume:  2007     ISSN:  1525-8882     ISO Abbreviation:  Sci. STKE     Publication Date:  2007 Apr 
Date Detail:
Created Date:  2007-04-25     Completed Date:  2007-05-11     Revised Date:  2009-11-19    
Medline Journal Info:
Nlm Unique ID:  100964423     Medline TA:  Sci STKE     Country:  United States    
Other Details:
Languages:  eng     Pagination:  pe16     Citation Subset:  IM    
Affiliation:
Germ Cell Development, Max-Planck-Institute for Biophysical Chemistry, Göttingen, Germany.
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MeSH Terms
Descriptor/Qualifier:
Animals
Apoptosis
Cell Differentiation
Cell Movement / physiology*
Chemotaxis
Drosophila Proteins / genetics,  physiology
Drosophila melanogaster / cytology*,  embryology
Embryo, Nonmammalian / cytology,  metabolism,  ultrastructure
Female
Germ Cells / cytology*
Gonads / cytology,  embryology
Male
Membrane Proteins / genetics,  physiology
Mice
Models, Biological
Phosphatidate Phosphatase / genetics,  physiology
Phospholipids / physiology
Proto-Oncogene Proteins c-kit / physiology
Stem Cell Factor / physiology
Chemical
Reg. No./Substance:
0/Drosophila Proteins; 0/Membrane Proteins; 0/Phospholipids; 0/Stem Cell Factor; EC 2.7.10.1/Proto-Oncogene Proteins c-kit; EC 3.1.3.4/Phosphatidate Phosphatase; EC 3.1.3.4/Wun2 protein, Drosophila; EC 3.1.3.4/wunen protein, Drosophila
Comments/Corrections
Comment In:
Sci STKE. 2007 Apr 24;2007(383):eg3   [PMID:  17456804 ]

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