| What is known about the mechanisms underlying SUDEP? | |
| | |
MedLine Citation:
|
PMID: 19087123 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
This article highlights studies in three major domains of potential mechanisms of sudden unexplained death in epilepsy (SUDEP): cardiac, respiratory, and autonomic. Ictal cardiac arrest is a clinically rare but well-recognized potential mechanism of SUDEP. Studies have failed to identify preexisting cardiac electrophysiologic or structural abnormalities that distinguish SUDEP persons. Some degree of pulmonary congestion is a common autopsy finding, but severe pulmonary edema occurs very rarely with seizures. In contrast, periictal apnea and hypoxia occur commonly with generalized tonic-clonic seizures and, to a lesser degree, with complex partial seizures. There are several animal models of postictal respiratory arrest. Postictal respiratory arrest in audiogenic seizure mice can be induced by serotonin receptor inhibition or prevented by selective serotonin reuptake inhibitor (SSRI) drugs. Reduced heart rate variability occurs in patients with refractory epilepsy and can be induced in animal seizure models, but its precise role in predisposing persons to sudden death requires further investigation. |
| | |
Authors:
|
Elson L So |
Related Documents
:
|
674883 - Transitory heart pacemaker for the prophylaxis of hypoxic cardiac standstill in cases o... 3687773 - Features of cardiac arrest episodes with and without acute myocardial infarction in the... 15831973 - Effects of focused force angioplasty: pre-clinical experience and clinical confirmation. |
Publication Detail:
|
Type: Journal Article; Review |
Journal Detail:
|
Title: Epilepsia Volume: 49 Suppl 9 ISSN: 1528-1167 ISO Abbreviation: Epilepsia Publication Date: 2008 Dec |
Date Detail:
|
Created Date: 2008-12-17 Completed Date: 2009-01-22 Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 2983306R Medline TA: Epilepsia Country: United States |
Other Details:
|
Languages: eng Pagination: 93-8 Citation Subset: IM |
Affiliation:
|
Department of Neurology, Mayo Clinic, Rochester, Minnesota 55905, USA. eso@mayo.edu |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Animals Autonomic Nervous System / physiopathology Death, Sudden / etiology*, pathology* Epilepsy / complications* Heart Diseases / complications Humans Lung Diseases / complications |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Hippocampal epileptogenesis in animal models of mesial temporal lobe epilepsy with hippocampal scler...
Next Document: Should all patients be told about sudden unexpected death in epilepsy (SUDEP)? Pros and Cons.