Document Detail


What influences the level of oxidative stress as measured by 8-hydroxy-2'-deoxyguanosine in patients on hemodialysis?
MedLine Citation:
PMID:  17072047     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Oxidative stress is at play in the progression of chronic renal failure (CRF) and in the genesis of atherosclerosis. The aim of the present study was to evaluate the factors that might influence the oxidative-antioxidative balance in patients on hemodialysis. The study group consisted of 71 hemodialysis patients due to CRF. Sixteen healthy subjects constituted a control group. The levels of 8-hydroxy-2'-deoxyguanosine (8-OHdG), C-reactive protein (CRP), and the blood lipid profile were measured in both groups. The results showed significantly higher mean levels of both 8-OHdG and CRP in the hemodialysis patients compared with that in the control subjects. The highest level of 8-OHdG was found in the subgroups of the patients with CRF primarily caused by diabetes (16.4 ng/ml) and with hypertensive nephropathy (15.8 ng/ml). More than a 2.5-fold higher level of 8-OHdG in the hemodialysis patients compared with the control subjects points to the presence of intensive oxidative stress in the patients.
Authors:
A Mastalerz-Migas; A Steciwko; M Pokorski; I Pirogowicz; J Drobnik; A Bunio; A Muszyńska; A Jasińska
Related Documents :
3439557 - Hemodialysis-associated acute subdural hematoma. interim management with peritoneal dia...
9461047 - Outbreaks of gram-negative bacterial bloodstream infections traced to probable contamin...
11576957 - Changes in body fat mass in male hemodialysis patients: a comparison between diabetics ...
6695947 - Elevated nicotine levels in patients undergoing hemodialysis. a role in cardiovascular ...
6233877 - Role of percutaneous transluminal coronary angioplasty in the treatment of unstable ang...
14611707 - Hemostatic system as a risk factor for cardiovascular disease in women with subclinical...
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Journal of physiology and pharmacology : an official journal of the Polish Physiological Society     Volume:  57 Suppl 4     ISSN:  1899-1505     ISO Abbreviation:  J. Physiol. Pharmacol.     Publication Date:  2006 Sep 
Date Detail:
Created Date:  2006-10-30     Completed Date:  2007-12-19     Revised Date:  2008-05-19    
Medline Journal Info:
Nlm Unique ID:  9114501     Medline TA:  J Physiol Pharmacol     Country:  Poland    
Other Details:
Languages:  eng     Pagination:  199-205     Citation Subset:  IM    
Affiliation:
Department of Family Medicine, Wroclaw Medical University, Wroclaw, Poland. agamigas@op.pl
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
Adult
Aged
C-Reactive Protein / metabolism
Deoxyguanosine / analogs & derivatives*,  blood
Diabetes Complications / blood
Glomerulonephritis / blood,  complications
Humans
Hypertension / blood,  complications
Kidney Failure, Chronic / blood*,  etiology,  therapy*
Middle Aged
Nephritis, Interstitial / blood,  complications
Oxidative Stress
Renal Dialysis*
Chemical
Reg. No./Substance:
0/8-hydroxy-2'-deoxyguanosine; 9007-41-4/C-Reactive Protein; 961-07-9/Deoxyguanosine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  The mentally ill: the way they perceive their own illness and their expectations from the society.
Next Document:  Prevalence of sleep apnea syndrome in hemodialyzed patients with end-stage renal disease.