Document Detail

What influences the level of oxidative stress as measured by 8-hydroxy-2'-deoxyguanosine in patients on hemodialysis?
MedLine Citation:
PMID:  17072047     Owner:  NLM     Status:  MEDLINE    
Oxidative stress is at play in the progression of chronic renal failure (CRF) and in the genesis of atherosclerosis. The aim of the present study was to evaluate the factors that might influence the oxidative-antioxidative balance in patients on hemodialysis. The study group consisted of 71 hemodialysis patients due to CRF. Sixteen healthy subjects constituted a control group. The levels of 8-hydroxy-2'-deoxyguanosine (8-OHdG), C-reactive protein (CRP), and the blood lipid profile were measured in both groups. The results showed significantly higher mean levels of both 8-OHdG and CRP in the hemodialysis patients compared with that in the control subjects. The highest level of 8-OHdG was found in the subgroups of the patients with CRF primarily caused by diabetes (16.4 ng/ml) and with hypertensive nephropathy (15.8 ng/ml). More than a 2.5-fold higher level of 8-OHdG in the hemodialysis patients compared with the control subjects points to the presence of intensive oxidative stress in the patients.
A Mastalerz-Migas; A Steciwko; M Pokorski; I Pirogowicz; J Drobnik; A Bunio; A Muszyńska; A Jasińska
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Journal of physiology and pharmacology : an official journal of the Polish Physiological Society     Volume:  57 Suppl 4     ISSN:  1899-1505     ISO Abbreviation:  J. Physiol. Pharmacol.     Publication Date:  2006 Sep 
Date Detail:
Created Date:  2006-10-30     Completed Date:  2007-12-19     Revised Date:  2008-05-19    
Medline Journal Info:
Nlm Unique ID:  9114501     Medline TA:  J Physiol Pharmacol     Country:  Poland    
Other Details:
Languages:  eng     Pagination:  199-205     Citation Subset:  IM    
Department of Family Medicine, Wroclaw Medical University, Wroclaw, Poland.
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MeSH Terms
C-Reactive Protein / metabolism
Deoxyguanosine / analogs & derivatives*,  blood
Diabetes Complications / blood
Glomerulonephritis / blood,  complications
Hypertension / blood,  complications
Kidney Failure, Chronic / blood*,  etiology,  therapy*
Middle Aged
Nephritis, Interstitial / blood,  complications
Oxidative Stress
Renal Dialysis*
Reg. No./Substance:
0/8-hydroxy-2'-deoxyguanosine; 9007-41-4/C-Reactive Protein; 961-07-9/Deoxyguanosine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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