| What has polar surface area ever done for drug discovery? | |
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MedLine Citation:
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PMID: 21452982 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
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Over the last decade, polar surface area (PSA) has become a ubiquitous term in medicinal and computational chemistry circles. This article charts the development of the increasingly efficient methods for the calculation of PSA before illustrating its usefulness through selected examples drawn from the medicinal chemistry literature. Consideration of PSA is shown to assist in the improvement of cellular potency, intestinal absorption and blood-brain barrier permeation or restriction to the peripheral circulation. |
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Authors:
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David E Clark |
Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Future medicinal chemistry Volume: 3 ISSN: 1756-8927 ISO Abbreviation: Future Med Chem Publication Date: 2011 Mar |
Date Detail:
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Created Date: 2011-04-01 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 101511162 Medline TA: Future Med Chem Country: England |
Other Details:
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Languages: eng Pagination: 469-84 Citation Subset: IM |
Affiliation:
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Argenta, 8/9 Spire Green Centre, Flex Meadow, Harlow, Essex, CM19 5TR, UK. david.clark@glpg.com. |
Export Citation:
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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