| What happens when replication and transcription complexes collide? | |
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MedLine Citation:
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PMID: 20581460 Owner: NLM Status: In-Process |
Abstract/OtherAbstract:
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The arrest of replication forks due to collisions with transcription complexes leads to genomic instability and cell death. Mechanisms that promote the progression of replication forks past transcription complexes are therefore essential for propagation and preservation of the genome. Recent studies of E. coli directly investigate the consequences of collisions of the replisome with RNAP polymerase (RNAP) in vitro and provide novel mechanisms by which these encounters may be resolved. Additionally, recent in vivo and in vitro studies support the longstanding hypothesis that auxiliary DNA helicases promote replication through roadblocks such as transcription complexes. Here we review past and recent advances that formulate our current understanding of how the bacterial replisome deals with transcription complexes along the path of chromosome duplication. |
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Authors:
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Richard T Pomerantz; Mike O'Donnell |
Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Cell cycle (Georgetown, Tex.) Volume: 9 ISSN: 1551-4005 ISO Abbreviation: Cell Cycle Publication Date: 2010 Jul |
Date Detail:
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Created Date: 2011-04-18 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 101137841 Medline TA: Cell Cycle Country: United States |
Other Details:
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Languages: eng Pagination: 2537-43 Citation Subset: IM |
Copyright Information:
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© 2010 Landes Bioscience |
Affiliation:
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The Rockefeller University, Howard Hughes Medical Institute, New York, NY, USA. |
Export Citation:
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Descriptor/Qualifier:
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| Grant Support | |
ID/Acronym/Agency:
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//Howard Hughes Medical Institute |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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