| What is the function of centrioles? | |
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MedLine Citation:
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PMID: 17115414 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The function of centrioles has been controversial and remains incompletely resolved. This is because centrioles, in and of themselves, do not directly perform any physiological activity. Instead, their role is only to act as a jig or breadboard onto which other functional structures can be built. Centrioles are primarily involved in forming two structures-centrosomes and cilia. Centrioles bias the position of spindle pole formation, but because spindle poles can self-organize, the function of the centriole in mitosis is not obligatory. Consequently, lack of centrioles does not generally prevent mitosis, although recent experiments suggest acentriolar spindles have reduced fidelity of chromosome segregation. In contrast, centrioles are absolutely required for the assembly of cilia, including primary cilia that act as cellular antennae. Consistent with this requirement, it is now becoming clear that many ciliary diseases, including nephronophthisis, Bardet-Biedl syndrome, Meckel Syndrome, and Oral-Facial-Digital syndrome, are caused by defects in centriole-associated proteins. |
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Authors:
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Wallace F Marshall |
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Publication Detail:
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Type: Journal Article; Review |
Journal Detail:
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Title: Journal of cellular biochemistry Volume: 100 ISSN: 0730-2312 ISO Abbreviation: J. Cell. Biochem. Publication Date: 2007 Mar |
Date Detail:
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Created Date: 2007-02-27 Completed Date: 2007-04-16 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8205768 Medline TA: J Cell Biochem Country: United States |
Other Details:
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Languages: eng Pagination: 916-22 Citation Subset: IM |
Affiliation:
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Department of Biochemistry and Biophysics, University of California, San Francisco, CA, USA. wmarshall@biochem.ucsf.edu |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Animals Bardet-Biedl Syndrome / metabolism, physiopathology Centrioles / metabolism, physiology* Cilia / metabolism, physiology Cytokinesis / physiology Humans Mitosis / physiology |
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