Document Detail


What drives the number of High Risk Human papillomavirus types in the anal canal in HIV-positive Men who have sex with Men?
MedLine Citation:
PMID:  23325914     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
We estimated the effect of sexual behavior, age and immunodeficiency on the number of High-Risk Human-Papillomavirus (HR-HPV) in the anal canal among HIV-positive men who have sex with men (MSM). Anal samples were genotyped with Linear Array and risk factors were investigated with Poisson regression. Of 586 MSM, 69% were Spanish, 25.6% Latin-Americans, median age 34.9 years (IQR: 30.1-40.8). Median number recent sexual partners was 6 (IQR: 2-24), median CD4-cell count was 531.5 cells/mm(3) (IQR: 403-701). Prevalence of any and multiple HR-HPV infections was 83.4% and 60.5%, respectively. Commonest types were HPV-16 (42%), HPV-51 (24%), HPV-39 (23.7%) and HPV-59 (23.5%). Age had a non-linear association with number of types, with the highest value around 35 years (p< 0.001); so did the number of recent sexual partners (p=0.033), which showed a fairly linear effect on the log-scale. The high prevalence of HR-HPV types is associated with recent sexual behavior and age.
Authors:
J Del Amo; C González; R B Geskus; M Torres; J Del Romero; P Vinciana; M Masiá; J R Blanco; B Hernández-Novoa; M Ortiz;
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2013-1-16
Journal Detail:
Title:  The Journal of infectious diseases     Volume:  -     ISSN:  1537-6613     ISO Abbreviation:  J. Infect. Dis.     Publication Date:  2013 Jan 
Date Detail:
Created Date:  2013-1-17     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0413675     Medline TA:  J Infect Dis     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Affiliation:
National Center of Epidemiology, Institute of Health Carlos III. Madrid. Spain.
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