Document Detail

What does global gene expression profiling tell us about the pathogenesis of systemic sclerosis?
MedLine Citation:
PMID:  24061076     Owner:  NLM     Status:  MEDLINE    
PURPOSE OF REVIEW: The purpose of this study is to review recent hypothesis-driven studies that utilize global gene expression data for elucidating the molecular basis of systemic sclerosis (SSc) and its various clinical manifestations.
RECENT FINDINGS: The longitudinal skin gene expression studies indicate that the previously identified molecular subsets are stable over time and might identify inherent subgroups of SSc patients. Skin transcript follow-up studies indicate that the Wnt/β-catenin pathway plays an important role in promotion of fibrogenesis in fibroblasts and preadipocytes. Furthermore, the transcript profile of sclerodermatous graft-versus-host disease (sclGVHD) mice resembles the skin transcriptomes of a subgroup of SSc patientswith IL13/IL4-inducible skin signature wherein the profibrotic chemokine CCL2 plays a key role. The comparison of skin biopsies from SSc patients to skin lesions of patients with cutaneous lupus and dermatomyositis has provided valuable information about the interferon (IFN) signature in these autoimmune diseases. Furthermore, plasma IFN-inducible chemokines correlate with the IFN gene expression score in SSc patients, enabling researchers to examine this molecular signature in large SSc cohorts with serum or plasma collection.
SUMMARY: Global gene expression profiling in skin and peripheral blood can contribute to a better understanding of SSc pathogenesis and identify novel biomarkers and therapeutic targets.
Shervin Assassi; Maureen D Mayes
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Review    
Journal Detail:
Title:  Current opinion in rheumatology     Volume:  25     ISSN:  1531-6963     ISO Abbreviation:  Curr Opin Rheumatol     Publication Date:  2013 Nov 
Date Detail:
Created Date:  2013-09-25     Completed Date:  2014-04-22     Revised Date:  2014-11-04    
Medline Journal Info:
Nlm Unique ID:  9000851     Medline TA:  Curr Opin Rheumatol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  686-91     Citation Subset:  IM    
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MeSH Terms
Disease Models, Animal
Gene Expression Profiling / methods*
Genetic Predisposition to Disease
Genome-Wide Association Study
HLA-DRB5 Chains / metabolism
Interferons / metabolism
Interleukin-13 / metabolism
Scleroderma, Systemic / genetics*,  metabolism
Skin / metabolism
Wnt Signaling Pathway / physiology
Grant Support
Reg. No./Substance:
0/HLA-DRB5 Chains; 0/Interleukin-13; 9008-11-1/Interferons

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