Document Detail

What do we (not) know about the management of blood pressure in acute stroke?
MedLine Citation:
PMID:  15509454     Owner:  NLM     Status:  MEDLINE    
Although it is indisputable that high blood pressure should be treated to prevent a first or a recurrent stroke, the management of high blood pressure in the first hours and days after stroke remains controversial. There is no high-quality evidence from randomized controlled trials to guide treatment in the 80% of patients who have elevated blood pressure during the first days after stroke. Theoretically, there are pros and cons for manipulating blood pressure after onset of stroke. Most treatment guidelines suggest leaving blood pressure untouched based on pathophysiologic principles. Post-hoc analyses from randomized trials, however, suggest that elevated blood pressure is associated with recurrent stroke and higher mortality, even after adjustment for potential confounders. On the other hand, preliminary studies have suggested that voluntarily increasing blood pressure might be beneficial in a selected subgroup of patients. In this overview, we present a summary of recent studies on this topic.
Annick Verstappen; Vincent Thijs
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Current neurology and neuroscience reports     Volume:  4     ISSN:  1528-4042     ISO Abbreviation:  Curr Neurol Neurosci Rep     Publication Date:  2004 Nov 
Date Detail:
Created Date:  2004-10-28     Completed Date:  2005-02-04     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  100931790     Medline TA:  Curr Neurol Neurosci Rep     Country:  United States    
Other Details:
Languages:  eng     Pagination:  505-9     Citation Subset:  IM    
Department of Neurology, University Hospital Gasthuisberg, Katholieke Universiteit Leuven, Herestraat 49, 3000 Leuven, Belgium.
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MeSH Terms
Blood Pressure / drug effects,  physiology*
Hypertension / etiology,  therapy*
Stroke / physiopathology*,  therapy

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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