| What a disorder: proinflammatory signaling pathways induced by Helicobacter pylori. | |
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MedLine Citation:
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PMID: 20863705 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Infection of gastric epithelial cells with Helicobacter pylori induces strong proinflammatory responses by activating nuclear transcription factors NF-κB and AP-1. Several reports indicate that multiple bacterial factors and cellular molecules are involved in this signaling. Injected peptidoglycan, CagA or OipA and urease, and at least 16 different signaling cascades have been implicated in H. pylori-induced proinflammatory signaling. Many of these reports are contradictory, thus generating a highly puzzling scenario. Here we discuss the pros and cons of the multiple signaling activities in the induction of proinflammatory responses and associated problems, and give suggestions for finding ways out of this dilemma. |
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Authors:
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Steffen Backert; Michael Naumann |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't Date: 2010-09-20 |
Journal Detail:
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Title: Trends in microbiology Volume: 18 ISSN: 1878-4380 ISO Abbreviation: Trends Microbiol. Publication Date: 2010 Nov |
Date Detail:
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Created Date: 2010-10-26 Completed Date: 2011-01-07 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9310916 Medline TA: Trends Microbiol Country: England |
Other Details:
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Languages: eng Pagination: 479-86 Citation Subset: IM |
Copyright Information:
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Copyright © 2010 Elsevier Ltd. All rights reserved. |
Affiliation:
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University College Dublin, School of Biomolecular and Biomedical Sciences, Belfield Campus, Dublin 4, Ireland. steffen.backert@ucd.ie |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Gastric Mucosa / immunology, metabolism, microbiology* Helicobacter Infections / immunology, microbiology* Helicobacter pylori / immunology*, metabolism, pathogenicity Humans NF-kappa B / metabolism Signal Transduction* |
| Chemical | |
Reg. No./Substance:
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0/NF-kappa B |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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