Document Detail


What determines the degradation rate of an injected protein?
MedLine Citation:
PMID:  6368146     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The fusion of cultured mammalian cells to red blood cells loaded with specific proteins provides a powerful system for the study of intracellular proteolysis. During the past four years the degradation rates of more than 30 proteins have been examined after their injection into HeLa cells. Results from these studies support the legitimacy of the microinjection approach. They also provide insight into the mechanism of intracellular proteolysis.
Authors:
M Rechsteiner; D Chin; R Hough; T McGarry; S Rogers; K Rote; L Wu
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Ciba Foundation symposium     Volume:  103     ISSN:  0300-5208     ISO Abbreviation:  Ciba Found. Symp.     Publication Date:  1984  
Date Detail:
Created Date:  1984-05-02     Completed Date:  1984-05-02     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  0356636     Medline TA:  Ciba Found Symp     Country:  NETHERLANDS    
Other Details:
Languages:  eng     Pagination:  181-201     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Animals
Antibodies, Monoclonal
Cell Fusion*
Cell Line
Erythrocytes / metabolism
Half-Life
Hela Cells / metabolism
Humans
Kinetics
Microinjections
Peptide Hydrolases / metabolism
Proteins / metabolism*
Chemical
Reg. No./Substance:
0/Antibodies, Monoclonal; 0/Proteins; EC 3.4.-/Peptide Hydrolases

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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