| What degree of maternal metabolic control in women with type 1 diabetes is associated with normal body size and proportions in full-term infants? | |
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MedLine Citation:
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PMID: 11023142 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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OBJECTIVE: To assess what degree of maternal metabolic control in women with type 1 diabetes is associated with normal fetal growth and results in normal neonatal body proportions in a group of full-term infants. RESEARCH DESIGN AND METHODS: We investigated the anthropometric characteristics of 98 full-term singleton infants born to 98 Caucasian women with type 1 diabetes enrolled within 12 weeks of gestation. The type 1 diabetic mother-infant pairs were divided into three groups on the basis of the daily glucose levels reached during the second and third trimesters of pregnancy (group 1: 37 mother-infant pairs with an average daily glucose level during the second and third trimesters of < or =95 mg/dl; group 2: 37 mother-infant pairs with an average daily glucose level during the second trimester of >95 mg/dl and during the third trimester of < or =95 mg/dl; group 3: 24 mother-infant pairs with an average daily glucose level during the second and third trimesters of >95 mg/dl; control group: 1,415 Caucasian mother-infant pairs with full-term singleton pregnancies and normal glucose challenge test screened for gestational diabetes. RESULTS: Infants of diabetic mothers in group 1 were similar to those of the control group in birth weight and in other anthropometric parameters. In contrast, offspring of diabetic mothers of groups 2 and 3 showed an increased incidence of large-for-gestational-age infants, significantly greater means of ponderal index and thoracic circumferences, and significantly smaller cranial/thoracic circumference ratios with respect to the control group. CONCLUSIONS: The results of our study suggest that, in diabetic pregnancies, only overall daily glucose values < or =95 mg/dl throughout the second and third trimesters can avoid alterations in fetal growth. |
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Authors:
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G Mello; E Parretti; F Mecacci; P La Torre; R Cioni; D Cianciulli; G Scarselli |
Publication Detail:
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Type: Comparative Study; Journal Article |
Journal Detail:
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Title: Diabetes care Volume: 23 ISSN: 0149-5992 ISO Abbreviation: Diabetes Care Publication Date: 2000 Oct |
Date Detail:
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Created Date: 2001-02-02 Completed Date: 2001-02-02 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 7805975 Medline TA: Diabetes Care Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 1494-8 Citation Subset: IM |
Affiliation:
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Second Obstetric and Gynecologic Clinic, Institute of Obstetrics and Gynecology, University of Florence, Italy. mellog@unifi.it |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adolescent Adult Analysis of Variance Birth Weight Blood Glucose / metabolism Body Constitution* Diabetes Mellitus, Type 1 / blood*, physiopathology European Continental Ancestry Group Female Fetal Macrosomia Gestational Age Humans Infant, Newborn* Infant, Small for Gestational Age Italy Pregnancy Pregnancy Trimester, Second Pregnancy Trimester, Third Pregnancy in Diabetics / blood*, physiopathology |
| Chemical | |
Reg. No./Substance:
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0/Blood Glucose |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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