| What caused the Black Death? | |
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MedLine Citation:
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PMID: 15879045 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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For the whole of the 20th century it was believed that the Black Death and all the plagues of Europe (1347-1670) were epidemics of bubonic plague. This review presents evidence that this view is incorrect and that the disease was a viral haemorrhagic fever, characterised by a long incubation period of 32 days, which allowed it to be spread widely even with the limited transport of the Middle Ages. It is suggested that haemorrhagic plague emerged from its animal host in Ethiopia and struck repeatedly at European/Asian civilisations, before appearing as the Black Death. The CCR5-Delta32 mutation confers protection against HIV-1 in an average of 10% of the people of European origin today. It is suggested that all the Deltaccr5 alleles originated from a single mutation event that occurred before 1000 BC and the subsequent epidemics of haemorrhagic plague gently forced up its frequency to 5 x 10(-5) at the time of the Black Death. Epidemics of haemorrhagic plague over the next three centuries then steadily raised the frequency in Europe (but not elsewhere) to present day values. |
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Authors:
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C J Duncan; S Scott |
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Publication Detail:
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Type: Historical Article; Journal Article |
Journal Detail:
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Title: Postgraduate medical journal Volume: 81 ISSN: 0032-5473 ISO Abbreviation: Postgrad Med J Publication Date: 2005 May |
Date Detail:
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Created Date: 2005-05-09 Completed Date: 2005-09-08 Revised Date: 2009-10-22 |
Medline Journal Info:
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Nlm Unique ID: 0234135 Medline TA: Postgrad Med J Country: England |
Other Details:
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Languages: eng Pagination: 315-20 Citation Subset: IM |
Affiliation:
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School of Biological Sciences, University of Liverpool, UK. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Disease Outbreaks
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history* Europe Hemorrhagic Fevers, Viral / history* History, 15th Century History, 16th Century History, 17th Century History, 18th Century History, 19th Century History, Medieval Humans Mutation / genetics Plague / genetics, history*, transmission Public Health / history Receptors, CCR5 / genetics Yersinia pestis |
| Chemical | |
Reg. No./Substance:
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0/Receptors, CCR5 |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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