Document Detail

What can we really tell women with multiple sclerosis regarding pregnancy? A systematic review and meta-analysis of the literature.
MedLine Citation:
PMID:  21401856     Owner:  NLM     Status:  Publisher    
Please cite this paper as: Finkelsztejn A, Brooks J, Paschoal F, Fragoso Y. What can we really tell women with multiple sclerosis regarding pregnancy? A systematic review and meta-analysis of the literature. BJOG 2011; DOI: 10.1111/j.1471-0528.2011.02931.x. Background  Although several papers report on pregnancy and multiple sclerosis (MS), no systematic review of the literature has been carried out. Neurologists and obstetricians need to have proper information to discuss with women presenting with MS who consider pregnancy. Objectives  Literature review and meta-analysis of data on pregnancy in women with MS. Search strategy  The present work followed the recommendations of the PRISMA Statement. Using the PICO framework, the authors independently searched for the terms 'pregnancy' OR 'gestation' OR 'pregnant' AND 'multiple sclerosis' OR 'MS' in the following databases: EMBASE/Excerpta Medica, Medline, Pubmed, Scopus, Index Medicus, Biomed Central, Ebsco Fulltext, LILACS, Scielo and the Cochrane Database of Systematic Reviews. Selection criteria: only papers presenting original work with analysis of at least one of the outcomes among pregnant women with MS were included. Data collection and analysis  Two independent workers performed the literature review. All the authors selected and read the relevant papers. Two other authors summarised data for analysis. Main results  Twenty-two papers reporting on 13 144 women with MS and their pregnancies were analysed. A significant decrease in relapse rate was observed during pregnancy, followed by a significant increase after delivery. Miscarriages, low birthweight, prematurity, neonatal death and malformations were assessed among these women and their offspring. There seems to be a regional influence on the rates of caesarean sections and abortions among women with MS. Neonatal death and malformation rates did not seem to be particularly high. Authors' conclusions  The present work provides evidence-based data that can be discussed with women with MS and their relatives when pregnancy is considered by these families.
A Finkelsztejn; Jbb Brooks; Fm Paschoal; Yd Fragoso
Related Documents :
12681876 - Gemeprost versus misoprostol for cervical priming before first-trimester abortion: a ra...
10895446 - Prediction of preterm birth by second trimester cervical sonography in twin pregnancies.
489466 - A radiographic study of the human fetal spine. 3. longitudinal growth.
24631176 - Gestational thyroid reference intervals in antibody-negative chinese women.
15554276 - Experience of laparoscopic tubal surgery at the department of obstetrics and gynecology...
24703426 - Optimising reproductive performance of beef cows and replacement heifers.
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2011-3-15
Journal Detail:
Title:  BJOG : an international journal of obstetrics and gynaecology     Volume:  -     ISSN:  1471-0528     ISO Abbreviation:  -     Publication Date:  2011 Mar 
Date Detail:
Created Date:  2011-3-15     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  100935741     Medline TA:  BJOG     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
© 2011 The Authors BJOG An International Journal of Obstetrics and Gynaecology © 2011 RCOG.
Department of Neurology, HC de Porto Alegre, Porto Alegre, RS, Brazil Department of Neurology, UNIMES and DRS-IV, Santos, SP, Brazil Department of Neurology, HC-USP, São Paulo, SP, Brazil.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Effects of coffee and tea consumption on urinary incontinence in female twins.
Next Document:  Validation of scales measuring self-efficacy and outcome expectancy in evidence-based practice.